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首页> 外文期刊>Journal of Clinical Microbiology >Phagocytic resistance of Escherichia coli K-1 isolates and relationship to virulence.
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Phagocytic resistance of Escherichia coli K-1 isolates and relationship to virulence.

机译：大肠杆菌K-1分离株的吞噬能力及其与毒力的关系。

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Blood culture isolates from 133 episodes of Escherichia coli bacteremia were typed for K-1 capsular antigen by immunodiffusion, utilizing equine antiserum raised against meningococcal group B polysaccharide. Twenty-six percent (34 of 133) of these isolates were positive for K-1 antigen. These 133 strains, 34 K-1 and 99 non-K-1, were tested for susceptibility to phagocytosis. K-1 strains were found to be more resistant to clearance (27%) than non-K-1 strains (71%) when tested in an in vitro opsonophagocytic/killing assay containing normal human granulocytes and plasma. Additional studies demonstrated that resistance was due to decreased phagocytosis rather than diminished intraleukocytic killing. K-1 strains obtained from stool showed a similar degree of resistance to phagocytosis when compared with K-1 blood isolates. A comparison of clinical data on non-neonatal patients with E. coli K-1 and non-K-1 bacteremia showed no significant differences in mortality for these two groups. The incidence of shock for patients bacteremic with K-1 strains (74%) was significantly greater than that for patients bacteremic with non-K-1 strains (33%). These differences are attributed to the increased resistance to phagocytosis observed for K-1 versus non-K-1 E. coli isolates.
机译：利用针对脑膜炎球菌B组多糖的马抗血清，通过免疫扩散对133种大肠杆菌菌血症的血培养分离株进行K-1荚膜抗原分型。这些分离物中的百分之二十六（133个中的34个）对K-1抗原呈阳性。测试了这133个菌株（34 K-1和99个非K-1）对吞噬作用的敏感性。当在包含正常人粒细胞和血浆的体外调理吞噬/杀死试验中进行测试时，发现K-1菌株对清除的抵抗力（27％）比非K-1菌株（71％）高。其他研究表明，耐药性是由于吞噬作用降低而不是白细胞内杀伤减少所致。与K-1血液分离株相比，从粪便中获得的K-1菌株对吞噬的抵抗力相似。对非新生儿大肠杆菌K-1和非K-1菌血症患者的临床数据进行比较后发现，两组的死亡率无显着差异。具有K-1菌株的细菌患者的休克发生率（74％）明显高于具有非K-1菌株的细菌患者的休克发生率（33％）。这些差异归因于K-1与非K-1大肠杆菌分离株对吞噬作用的抵抗力增强。

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