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首页> 外文期刊>Journal of Clinical Microbiology >Candida antigenemia, as detected by passive hemagglutination inhibition, in patients with disseminated candidiasis or Candida colonization.
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Candida antigenemia, as detected by passive hemagglutination inhibition, in patients with disseminated candidiasis or Candida colonization.

机译：散发性念珠菌病或念珠菌定植的患者中通过被动血凝抑制检测到的念珠菌抗原血症。

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摘要

A passive hemagglutination inhibition assay was studied by using a hyperimmune serum from rabbits immunized with whole yeast cells (Candida albicans group A). This technique was effective at detecting small amounts of laboratory-prepared mannan or a whole-cell extract of C. albicans. Of 32 patients with documented disseminated candidiasis that were tested, 19 showed evidence of circulating antigen by passive hemagglutination inhibition. Three of these patients showed only partial, rather than complete, inhibition. Among 22 colonized patients, 4 showed partial inhibition, and none of 49 normal controls demonstrated inhibition. All of the sera were tested for antibody by agglutination, immunodiffusion, and passive hemagglutination. This last technique added increased sensitivity, but not specificity, to the standard tests already in use. Fourfold or greater titer rises by passive hemagglutination occurred in fewer than one-third of patients with invasive candidiasis and developed in more than one-half of patients who were colonized and did not require systemic anticandida therapy.
机译：通过使用全酵母细胞（白色念珠菌A组）免疫的兔子的超免疫血清研究了被动血凝抑制试验。此技术可有效检测实验室制备的少量甘露聚糖或白色念珠菌的全细胞提取物。在测试的32例散发性念珠菌病患者中，有19例通过被动血凝抑制显示了循环抗原的证据。其中三名患者仅表现出部分抑制，而不是完全抑制。在22例定植的患者中，有4例显示部分抑制，而49例正常对照中均未显示抑制。通过凝集，免疫扩散和被动血凝来测试所有血清的抗体。最后一种技术为已经使用的标准测试增加了灵敏度，但没有增加特异性。在不到三分之一的浸润性念珠菌病患者中，被动血凝引起的滴度升高了四倍或更多，而在超过一半的定植且不需要全身性抗虱药治疗的患者中，滴度升高了四倍或更多。

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