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首页> 外文期刊>Journal of Clinical Microbiology >Development of a simple serological method for diagnosing leptospirosis: a microcapsule agglutination test.
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Development of a simple serological method for diagnosing leptospirosis: a microcapsule agglutination test.

机译：诊断钩端螺旋体病的简单血清学方法的开发：微囊凝集试验。

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摘要

A passive microcapsule agglutination test for the diagnosis of leptospirosis was developed by utilizing chemically stable microcapsules instead of sheep erythrocytes. In the test, sonically disrupted antigens of leptospira were sensitized to microcapsules treated with glutaraldehyde. Compared with the microscopic agglutination test, the passive microcapsule agglutination test showed a relatively genus-specific tendency and a 4- to 32-fold-higher sensitivity. The sensitized microcapsule antigens were stable for at least 1 year. The microcapsules coupled with mixed antigens can be used as a serodiagnostic screening test for diseases caused by various types of leptospira. The test, which is very simple and reproducible and requiring no specific training, can be employed easily as a routine test in diagnostic laboratories.
机译：通过利用化学稳定的微囊代替绵羊红细胞，开发了一种用于诊断钩端螺旋体病的被动微囊凝集试验。在该测试中，钩端螺旋体的声波破坏抗原被戊二醛处理过的微囊敏感。与显微凝集试验相比，被动微胶囊凝集试验显示出相对属特异性的趋势和4至32倍高的敏感性。致敏的微囊抗原稳定至少1年。结合有混合抗原的微胶囊可用作针对各种钩端螺旋体引起的疾病的血清诊断筛查试验。该测试非常简单，可重复且不需要特殊培训，可以轻松地用作诊断实验室的常规测试。

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