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首页> 外文期刊>Journal of Clinical Microbiology >Genomic variation of adenovirus type 5 isolates recovered from bone marrow transplant recipients.
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Genomic variation of adenovirus type 5 isolates recovered from bone marrow transplant recipients.

机译:从骨髓移植受体中回收的5型腺病毒分离株的基因组变异。

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We characterized the genomic variation of adenovirus type 5 isolates recovered from bone marrow transplant recipients in Seattle between 1976 and 1982. By restriction endonuclease analysis, we identified three new adenovirus genomic variants, each associated with a single invasive adenovirus infection. In addition, we were able to obtain suggestive evidence for a nosocomial spread of a particular group of isolates within this population. This study demonstrates that the technique of restriction endonuclease analysis is an important epidemiological tool for investigating viral infections.
机译:我们表征了1976年至1982年之间从西雅图的骨髓移植受者中回收的5型腺病毒分离株的基因组变异。通过限制性核酸内切酶分析,我们鉴定了三个新的腺病毒基因组变异体,每个变异体均与单个侵袭性腺病毒感染相关。此外,我们能够获得该人群中特定分离株群在医院内传播的提示性证据。这项研究表明限制性核酸内切酶分析技术是调查病毒感染的重要流行病学工具。

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