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首页> 外文期刊>Journal of Clinical Microbiology >Efficacy of Antimicrobial Treatments and Vaccination Regimens for Control of Porcine Reproductive and Respiratory Syndrome Virus and Streptococcus suis Coinfection of Nursery Pigs
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Efficacy of Antimicrobial Treatments and Vaccination Regimens for Control of Porcine Reproductive and Respiratory Syndrome Virus and Streptococcus suis Coinfection of Nursery Pigs

机译：抗菌治疗和疫苗接种方案对猪繁殖与呼吸综合征病毒和猪链球菌共感染的控制效果

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Seventy-six, crossbred, porcine reproductive and respiratory syndrome virus (PRRSV)-free pigs were weaned at 12 days of age and randomly assigned to seven groups of 10 to 11 pigs each. Pigs in group 1 served as unchallenged controls. Pigs in groups 2 to 7 were challenged intranasally with 2 ml of high-virulence PRRSV isolate VR-2385 (104.47 50% tissue culture infective doses per 2 ml) on day 0 of the study (30 days of age). Seven days after PRRSV challenge, pigs in groups 2 to 7 were challenged intranasally with 2 ml of Streptococcus suis serotype 2 (108.30 CFU/2 ml). Group 2 pigs served as untreated positive controls. Antimicrobial treatments included daily intramuscular injection with 66,000 IU of procaine penicillin G per kg of body weight on days 8 to 10 (group 3), drinking water medication with 23.1 mg of tiamulin per kg during days 8 to 10 (group 4), and daily intramuscular injection of 5.0 mg of ceftiofur hydrochloride per kg on days 8 to 10 (group 5). Vaccination regimens included two intramuscular doses of an autogenous killedS. suis vaccine (group 6) prior to S. suischallenge or a single 2-ml intramuscular dose of an attenuated live PRRSV vaccine (group 7) 2 weeks prior to PRRSV challenge. Mortality was 0, 63, 45, 54, 9, 40, and 81% in groups 1 to 7, respectively. Ceftiofur treatment was the only regimen that significantly (P < 0.05) reduced mortality associated with PRRSV and S. suis coinfection. The other treatments and vaccinations were less effective. We conclude that ceftiofur administered by injection for three consecutive days following S. suis challenge was the most effective regimen for minimizing disease associated with PRRSV and S. suiscoinfection.
机译：在十二日龄时对76头无猪繁殖和呼吸综合症病毒（PRRSV）的猪进行断奶，并随机分为7组，每组10-11头猪。第1组中的猪用作无挑战的对照。在研究的第0天（30天），对2至7组的猪鼻内用2 ml高毒PRRSV分离株VR-2385（每2 ml 10 4.47 50％组织培养感染剂量）进行鼻攻击。年龄）。 PRRSV攻击后7天，第2至7组的猪经鼻内用2 ml猪链球菌血清型2（10 8.30 CFU / 2 ml）进行攻击。第2组猪用作未治疗的阳性对照。抗菌药物治疗包括在第8天至第10天每天肌肉注射每公斤体重66,000 IU普鲁卡因青霉素G（第3组），在第8天到第10天每天以每公斤体重23.1 mg饮水的饮水药物（第4组）和每天在第8到10天每公斤肌注5.0毫克头孢噻呋盐酸盐（第5组）。疫苗接种方案包括两次肌肉注射的自体杀死的emS。 S之前的suis 疫苗（第6组）。挑战或在PRRSV攻击前2周肌注2毫升肌肉注射减毒活PRRSV疫苗（第7组）。第1至7组的死亡率分别为0％，63％，45％，54％，9％，40％和81％。头孢噻呋治疗是唯一显着（ P <0.05）降低PRRSV和 S相关死亡率的方案。 suis 共感染。其他治疗和疫苗接种效果较差。我们得出的结论是， S后连续三天注射头孢噻呋。 suis 挑战是使PRRSV和 S相关疾病最小化的最有效方案。猪共感染。

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