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首页> 外文期刊>Journal of Clinical Microbiology >Correlation of Plasmodium falciparum gametocytemia with complement component titers in rural Nigerian school children.
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Correlation of Plasmodium falciparum gametocytemia with complement component titers in rural Nigerian school children.

机译：尼日利亚农村小学生恶性疟原虫配子体细胞增多症与补体成分滴度的相关性。

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摘要

The relationship between Plasmodium falciparum gametocytemia and the complement components C3, C4, and C3b was investigated in 141 ambulant rural Nigerian school children. Three groups were studied. Group 1 included 42 children with circulating P. falciparum gametocytemia in which the mean titers of C3, C4, and C3b were 145.4 +/- 22.6 mg/100 ml (72%), 60.5 +/- 0.2 mg/100 ml (149%), and 64.0 +/- 5.9 mg/liter (65%), respectively. These findings indicated marked C3b hypocomplementemia. Group 2 included 50 children who were used as controls and lacked malaria parasitemia. C3, C4, and C3b mean titers were 161.6 +/- 28.9 mg/100 ml (80%), 56.8 +/- 2.07 mg/100 ml (140%), and 84.8 +/- 11.4 mg/liter (86%), respectively. Group 3 included 49 children with other blood stages of P. falciparum parasitemia but no gametocytes. C3, C4, and C3b mean titers in this group were 103.0 mg/100 ml (51%), 18.3 +/- 1.2 mg/100 ml (45%), and 90.7 mg/liter (92%), respectively. Our findings suggest that C3b hypocomplementemia may be related to the advent of circulating P. falciparum gametocytes in children. We also confirmed C3 and C4 hypocomplementemia in acute human malaria. The implication of our findings in relation to neat in vitro culture of P. falciparum gametocytes or total inhibition of gametocytogenesis in malaria control is still speculative.
机译：在141名尼日利亚农村流动学童中调查了恶性疟原虫配子体细胞增多症与补体成分C3，C4和C3b之间的关系。研究了三组。第一组包括42例循环性恶性疟原虫配体细胞瘤的儿童，其中C3，C4和C3b的平均滴度分别为145.4 +/- 22.6 mg / 100 ml（72％），60.5 +/- 0.2 mg / 100 ml（149％ ）和64.0 +/- 5.9毫克/升（65％）。这些发现表明明显的C3b补体不足。第2组包括50名被用作对照且没有疟疾寄生虫病的儿童。 C3，C4和C3b平均滴度为161.6 +/- 28.9 mg / 100 ml（80％），56.8 +/- 2.07 mg / 100 ml（140％）和84.8 +/- 11.4 mg /升（86％） ， 分别。第3组包括49名患有恶性疟原虫寄生虫血其他阶段但无配子体细胞的儿童。该组中的C3，C4和C3b平均滴度分别为103.0 mg / 100 ml（51％），18.3 +/- 1.2 mg / 100 ml（45％）和90.7 mg / L（92％）。我们的发现表明，C3b补体血症可能与儿童循环恶性疟原虫配子细胞的出现有关。我们还证实了急性人类疟疾中的C3和C4低补体血症。我们的发现与恶性疟原虫配子细胞的纯净体外培养或在疟疾控制中完全抑制配子细胞生成有关的推测仍是推测。

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