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首页> 外文期刊>Journal of Clinical Microbiology >Delayed hypersensitivity to heart antigens in Chagas' disease as measured by in vitro lymphocyte stimulation.
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Delayed hypersensitivity to heart antigens in Chagas' disease as measured by in vitro lymphocyte stimulation.

机译：通过体外淋巴细胞刺激测定，在恰加斯氏病中对心脏抗原的迟发型超敏反应。

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Reactivity to Trypanosoma cruzi antigens and autoreactivity to heart antigens were evaluated in 27 patients with Chagasic cardiomyopathy (group I), 52 patients without evidence of cardiac dysfunction (group II), and 36 selected controls, either healthy patients or patients with other heart diseases (group III). The in vitro lymphoblastogenesis response to T. cruzi antigens was found to be high in groups I and II and low in group III. The mean stimulation index to T. cruzi antigens, in fact, tended to be highest in group I, suggesting a more intense immune response in patients with Chagasic cardiomyopathy. The proportion of individuals with reactivity to heart antigens was 28.6% in group I, 25% in group II, and 0% in group III. The finding of an equal percentage of reactivity to heart antigens in groups I and II was unexpected, as a higher incidence of positive reactions in group I was predicted. Consequently, it is thought that this finding and its relevance to the pathogenic process of Chagasic cardiomyopathy need to be carefully assessed in a longitudinal study.
机译：在27例Chagasic心肌病患者（I组），52例无心脏功能障碍证据的患者（II组）和36例选定的对照中评估了克鲁斯锥虫抗原的反应性和对心脏抗原的自身反应性（健康组或其他心脏病患者）第三组）。发现在第一和第二组中对克鲁斯氏锥虫抗原的体外淋巴母细胞生成反应高而在第三组中较低。实际上，在第一组中，对克氏锥虫抗原的平均刺激指数趋于最高，表明在恰加斯型心肌病患者中免疫反应更为强烈。与心脏抗原具有反应性的个体比例在第一组中为28.6％，在第二组中为25％，在第三组中为0％。在I和II组中发现与心脏抗原反应性相等的百分比是出乎意料的，因为预计在I组中阳性反应的发生率会更高。因此，认为在纵向研究中需要仔细评估这一发现及其与恰加斯型心肌病致病过程的相关性。

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