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首页> 外文期刊>Journal of Clinical Microbiology >Hemolysin and K antigens in relation to serotype and hemagglutination type of Escherichia coli isolated from extraintestinal infections.
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Hemolysin and K antigens in relation to serotype and hemagglutination type of Escherichia coli isolated from extraintestinal infections.

机译：与从肠外感染分离的大肠杆菌的血清型和血凝型有关的溶血素和K抗原。

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Escherichia coli isolated from cases of bacteremia and from a variety of urinary tract infections were characterized according to serotype (O:H antigenicity), K type (possession of K1, K2, K3, K12, or K13), hemagglutination (HA) type, and production of beta-hemolysin. Results obtained with the bacteremia and urinary tract infection isolates were similar except for more hemolytic isolated from urine than from blood (42 versus 29%) and more K1+ isolates from blood than from urine (50 versus 29%). A close correlation was found between Ha type VI (production of fimbriae which mediate mannose-resistant HA of human and African green monkey erythrocytes) and the production of hemolysin or K1 capsular antigen or both. Most (95 of 98, or 95%) of the HA type VI+ blood isolates and most (146 of 164, or 89%) of the HA type VI+ urine isolates produced hemolysin or K1 or both, in contrast to 22 and 26%, respectively, of those belonging to HA types other than HA type VI. Also, 76% of all hemolytic and 70% of all K1+ isolates belonged to HA type VI. Remarkably few of the HA type VI+ isolates (13%) and even fewer of the HA type VI- isolates (3%) produced both K1 and hemolysin; these belonged mainly to serotypes O16:H6, O18:H7 and O2:H4. Other major serogroups were usually K1+/hemolysin- (O1, O7) or K1-/hemolysin+ (O2, O4, O6). At least 74% (262 of 351) and possibly as many as 83% (293 of 351) of those isolates which produced mannose-resistant HA of human erythrocytes were classified as HA type VI+; 31 isolates produced mannose-resistant HA with all erythrocytes tested. Taking serogroup and serotype into consideration, we conclude that the E. coli fimbrial hemagglutinin(s) responsible for the HA type VI phenotype will prove to be the same as the virulence-associated mannose-resistant adhesins of uropathogenic E. coli which other investigators have characterized as unique fimbrial antigens detectable by mannose-resistant HA of human erythrocytes.
机译：从菌血症和各种尿路感染病例中分离出的大肠杆菌根据血清型（O：H抗原性），K型（拥有K1，K2，K3，K12或K13），血凝（HA）型来表征，和生产β-溶血素。用菌血症和尿路感染分离株获得的结果相似，除了从尿液中分离出的溶血比从血液中分离的多（42比29％），从血液中分离出的K1 +分离物比从尿液中分离出的K1 +更多（50对29％）。发现Ha型VI（介导人类和非洲绿猴红细胞对甘露糖抗性HA的菌毛的产生）与溶血素或K1荚膜抗原或两者的产生之间密切相关。大部分（98种中的95种，即95％）的HA型VI +血液分离物和大多数（164种中的146种，即89％）的HA型VI +血液分离物产生了溶血素或K1或两者，而22％和26％分别属于HA类型VI之外的其他HA类型。同样，所有溶血性细菌中的76％和所有K1 +分离物中70％属于HA型VI。产生K1和溶血素的HA型VI +分离株极少（13％），而HA型VI-分离株甚至更少（3％）。这些主要属于血清型O16：H6，O18：H7和O2：H4。其他主要血清群通常是K1 + /溶血素-（O1，O7）或K1- /溶血素+（O2，O4，O6）。产生人红细胞对甘露糖有抗性的HA的分离物中，至少有74％（351个中的262个），可能多达83％（351个中的293个）被归类为HA +型。 31个分离物产生了耐甘露糖的HA，并测试了所有红细胞。考虑到血清群和血清型，我们得出结论，负责HA VI型表型的大肠杆菌纤维血凝素将与其他致病性大肠杆菌的与毒力相关的甘露糖抗性粘附素相同。其特征是可被人红细胞的甘露糖抗性HA检测到的独特纤维抗原。

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