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首页> 外文期刊>Journal of Clinical Microbiology >Expression of gamma interferon on circulating lymphocytes in viral infections.
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Expression of gamma interferon on circulating lymphocytes in viral infections.

机译：在病毒感染中循环淋巴细胞上γ干扰素的表达。

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Peripheral blood lymphocytes from a total of 111 patients and 40 healthy individuals were studied for gamma interferon (IFN-gamma) expression on their surfaces by indirect immunofluorescence assay and flow cytometry, with a new anti-IFN-gamma monoclonal antibody (IGMB-14) as a specific reagent. Of 64 patients with proven acute viral infections, 59 had a significantly higher percentage of lymphocytes expressing IFN-gamma on their membranes than healthy individuals did. On the other hand, only 3 (8.9%) of 34 patients with proven bacterial infections had an increased percentage of IFN-gamma-expressing lymphocytes. None of the eight patients with other infections and none of the five with systemic lupus erythematosus showed an increased percentage of IFN-gamma-positive lymphocytes. The percentage of IFN-gamma-expressing lymphocytes during a viral infection was found to be related to different stages of the disease. Finally, some applications of this rapid IFN-gamma assay method in viral diseases are discussed.
机译：通过间接免疫荧光测定和流式细胞仪，使用一种新型抗IFN-γ单克隆抗体（IGMB-14），研究了111名患者和40名健康个体的外周血淋巴细胞表面γ干扰素（IFN-γ）的表达。作为特定试剂。在确诊为急性病毒感染的64位患者中，有59位的淋巴细胞在其膜上表达IFN-γ的百分比明显高于健康个体。另一方面，在确诊细菌感染的34名患者中，只有3名（8.9％）的IFN-γ表达淋巴细胞百分比增加。八名其他感染患者和五名系统性红斑狼疮患者均未显示IFN-γ阳性淋巴细胞百分比增加。发现在病毒感染期间表达IFN-γ的淋巴细胞的百分数与疾病的不同阶段有关。最后，讨论了这种快速IFN-γ检测方法在病毒性疾病中的一些应用。

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