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首页> 外文期刊>Journal of Clinical Microbiology >Immunologic abnormalities in chronic fatigue syndrome.
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Immunologic abnormalities in chronic fatigue syndrome.

机译：慢性疲劳综合征的免疫学异常。

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The chronic fatigue syndrome (CFS), formerly known as chronic Epstein-Barr virus syndrome, is a clinical state of some complexity and uncertain etiology. In order to characterize in a comprehensive manner the status of laboratory markers associated with cellular immune function in patients with this syndrome, 30 patients with clinically defined CFS were studied. All of the subjects were found to have multiple abnormalities in these markers. The most consistent immunological abnormality detected among these patients, when compared with normal controls, was low natural killer (NK) cell cytotoxicity. The number of NK cells, as defined by reactivity with monoclonal antibody NKH.1 (CD56), was elevated, but the killing of K562 tumor cells per CD56 cell was significantly diminished. Lymphoproliferative responses after stimulation with phytohemagglutinin and pokeweed mitogen were decreased in most patients when compared with those in normal controls, as was the production of gamma interferon following mitogen stimulation. Lymphocyte phenotypic marker analysis of peripheral blood lymphocytes showed that there were significant differences between patients with CFS and controls. There was an increase in the percentage of suppressor-cytotoxic T lymphocytes, CD8, and a proportionally larger increase in the number of CD8 cells expressing the class II activation marker. Most patients had an elevated number of CD2 cells which expressed the activation marker CDw26. The numbers of CD4 cells and the helper subset of CD4+CD29+ cells in patients with CFS were not different from those in controls. There was, however, a significant decrease in the suppressor inducer subset of CD4+ CD45RA+ cells. The number of B cells, CD20 and CD21, were elevated, as were the numbers of a subset of B cells which coexpressed CD20 and CD5. The patterns of immune marker abnormalities observed was compatible with a chronic viral reactivation syndrome.
机译：慢性疲劳综合症（CFS），以前称为慢性爱泼斯坦-巴尔病毒综合症，是一种具有某些复杂性和病因的临床状态。为了全面表征该综合征患者与细胞免疫功能相关的实验室标志物的状态，研究了30名临床定义为CFS的患者。发现所有受试者在这些标志物中均具有多个异常。与正常对照相比，这些患者中检测到的最一致的免疫学异常是自然杀伤（NK）细胞毒性较低。由与单克隆抗体NKH.1（CD56）的反应性所定义的NK细胞数量有所增加，但每个CD56细胞对K562肿瘤细胞的杀灭作用却大大减少了。与正常对照组相比，大多数患者用植物血凝素和商陆有丝分裂原刺激后的淋巴增生反应降低，有丝分裂原刺激后γ干扰素的产生也降低了。外周血淋巴细胞的淋巴细胞表型标记分析表明，CFS患者与对照组之间存在显着差异。抑制性细胞毒性T淋巴细胞CD8的百分比增加，并且表达II类激活标记的CD8细胞的数量成比例地增加。大多数患者的CD2细胞表达激活标记CDw26的数量增加。 CFS患者的CD4细胞数量和CD4 + CD29 +细胞的辅助亚群与对照组无差异。但是，CD4 + CD45RA +细胞的抑制诱导子亚群明显减少。 B细胞CD20和CD21的数量增加，共同表达CD20和CD5的B细胞子集的数量也增加。观察到的免疫标记异常的模式与慢性病毒再激活综合征相适应。

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