Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen.

D Lavanchy; C Mayerat; B Morel; P Schneider; C Zufferey; J J Gonvers; A Pécoud; P C Frei

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Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen.

机译：评价用于检测抗丙型肝炎病毒（HCV）抗体的第三代测定，并与对c100-3抗原有反应的献血者中HCV RNA的存在进行比较。

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We tested serum samples from blood donors by using first-, second-, and third-generation enzyme immunoassays or recombinant immunoblot assays. Second- and third-generation assays gave comparable results. Circulating hepatitis C virus RNA was found in a high proportion of reactive samples. A lack of reactivity or low-level reactivity predicted the absence of hepatitis C virus RNA in 100% of the cases.

机译：我们使用第一代，第二代和第三代酶免疫测定法或重组免疫印迹测定法测试了来自献血者的血清样品。第二代和第三代测定得出了可比的结果。在高比例的反应性样品中发现了循环丙型肝炎病毒RNA。缺乏反应性或低水平反应性预示着在100％的病例中不存在丙型肝炎病毒RNA。

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《Journal of Clinical Microbiology》 |1994年第9期|共4页
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D Lavanchy; C Mayerat; B Morel; P Schneider; C Zufferey; J J Gonvers; A Pécoud; P C Frei;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Indeterminate third-generation hepatitis C recombinant immunoblot assay and HCV RNA analysis: isolated reactivity against NS5 associated with HCV viraemia in clinical patients but not blood donors. [J] . Cavazza S, Lagging M Scandinavian journal of infectious diseases. . 2005,第6a7期

机译：不确定的第三代丙型肝炎重组免疫印迹分析和HCV RNA分析：临床患者而非献血者中针对与HCV病毒血症相关的NS5的孤立反应性。
2. Performance evaluation of the Aptima (R) HCV Quant Dx assay for hepatitis C virus (HCV) RNA detection and quantification in comparison to the Abbott RealTime HCV assay [J] . Garbuglia Anna Rosa, Bibbo Angela, Sciamanna Roberta, Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology . 2017,第期

机译：与Abbott Realtime HCV测定相比，丙型肝炎病毒（HCV）RNA检测和定量的APTIMAHCV量子DX测定的性能评价
3. Evaluation of a Membrane Filter Assay System, Ortho HCV Ab Quik Pack, for Detection of Anti-Hepatitis C Virus Antibody [J] . Takanari Kodama, Satoshi Ichiyama, Kumiko Sato, Journal of Clinical Microbiology . 1998,第5期

机译：评估用于检测抗丙型肝炎病毒抗体的膜滤器检测系统Ortho HCV Ab Quik Pack
4. European Evaluation of the LCx HCV RNA Quantitative Assay, a Combined Solution for both Qualitative and Quantitative Assessment of HCV RNA [C] . S. Thamm*, J. Smith**, G. Michel*, European Congress of Virology . 2004

机译：欧洲评价LCX HCV RNA定量测定，用于定性和定量评估HCV RNA的组合溶液
5. Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen. [O] . D Lavanchy, C Mayerat, B Morel, 1994

机译：评价用于检测抗丙型肝炎病毒（HCV）抗体的第三代测定并与对c100-3抗原有反应的献血者中HCV RNA的存在进行比较。
6. The effect of screening for HCV (C100-3) antibody in donor blood evaluated from the relationship between optical density of first and second generation screening method and HCV-RNA by polymerase chain reaction (PCR). [O] . Hirohito Honda, Shingo Hibino, Masako Kamamura, 1993

机译：通过聚合酶链反应（PCR）从第一和第二代筛选方法和HCV-RNA的光密度与HCV-RNA之间的关系评估供体血液中HCV（C100-3）抗体的影响。

Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen.

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