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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Typing of Environmental and Patient Isolates of Aspergillus fumigatus from Various Hospital Settings
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Molecular Typing of Environmental and Patient Isolates of Aspergillus fumigatus from Various Hospital Settings

机译：不同医院环境中烟曲霉环境和患者分离株的分子分型

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摘要

Fingerprinting of more than 700 clinical and environmental isolates of Aspergillus fumigatus from four differential hospital settings was undertaken with a dispersed repeated DNA sequence. The analysis of the environmental isolates showed that the airborneA. fumigatus population is extremely diverse, with 85% of the strains being represented as a single genotype isolated once. The remaining 15% of the strains were isolated several times and were able to persist for several months in the same hospital environment. No strains were found to be associated with a specific location inside the hospital, and identical strains were isolated from different buildings of the hospital and outdoors. Isolation of the same strain both from patients and from the environment of the same hospital is highly suggestive of a nosocomial infection. The characteristics of the environmental fungal population explains the two main results obtained from the typing of the clinical isolates: (i) the absence of a common strain responsible for an invasive aspergillosis outbreak results from the extreme diversity of the environmental population of A. fumigatus in contact with the patients, and (ii) patients hospitalized in different wards of the same hospital can be infected with the same strain since every patient might inhale the same spore population.
机译：使用分散的重复DNA序列对来自四个不同医院环境的700株烟曲霉的临床和环境分离株进行了指纹分析。对环境分离物的分析表明，空气传播的 A。烟气种群非常多样化，其中有85％的菌株以一次分离的单一基因型表示。其余的15％菌株经过几次分离，能够在同一医院环境中持续数月。没有发现与医院内部特定位置相关的菌株，并且从医院的不同建筑物和室外分离出相同的菌株。从患者和同一家医院的环境中分离出同一菌株，强烈提示医院感染。环境真菌种群的特征解释了从临床分离株的分类中获得的两个主要结果：（i）缺乏造成侵袭性曲霉病暴发的常见菌株，这是由于 A环境种群的极端多样性造成的。 （ii）在同一家医院不同病房住院的患者可以感染同一株，因为每位患者都可能吸入相同的孢子种群。

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