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首页> 外文期刊>Journal of Clinical Microbiology >Outbreak of Bacillus cereus Infections in a Neonatal Intensive Care Unit Traced to Balloons Used in Manual Ventilation
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Outbreak of Bacillus cereus Infections in a Neonatal Intensive Care Unit Traced to Balloons Used in Manual Ventilation

机译：新生儿重症监护病房的蜡状芽孢杆菌感染暴发，其原因是人工通气中使用了气球

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In 1998, an outbreak of systemic infections caused byBacillus cereus occurred in the Neonatal Intensive Care Unit of the University Hospital Vrije Universiteit, Amsterdam, The Netherlands. Three neonates developed sepsis with positive blood cultures. One neonate died, and the other two neonates recovered. An environmental survey, a prospective surveillance study of neonates, and a case control study were performed, in combination with molecular typing, in order to identify potential sources and transmission routes of infection. Genotypic fingerprinting by amplified-fragment length polymorphism (AFLP) showed that the three infections were caused by a single clonal type of B. cereus. The same strain was found in trachea aspirate specimens of 35 other neonates. The case control study showed mechanical ventilation with a Sensormedics ventilation machine to be a risk factor for colonization and/or infection (odds ratio, 9.8; 95% confidence interval, 1.1 to 88.2). Prospective surveillance showed that colonization with B. cereusoccurred exclusively in the respiratory tract of mechanically ventilated neonates. The epidemic strain of B. cereus was found on the hands of nursing staff and in balloons used for manual ventilation. Sterilization of these balloons ended the outbreak. We conclude that B. cereus can cause outbreaks of severe opportunistic infection in neonates. Typing by AFLP proved very useful in the identification of the outbreak and in the analysis of strains recovered from the environment to trace the cause of the epidemic.
机译：1998年，由荷兰芽孢杆菌引起的全身感染暴发在荷兰阿姆斯特丹的弗里耶大学大学医院新生儿重症监护室发生。三名新生儿发展为败血症，血液培养呈阳性。一名新生儿死亡，另两名新生儿康复。结合分子分型，进行了一项环境调查，一项前瞻性新生儿监测研究以及一项病例对照研究，以确定潜在的感染源和传播途径。通过扩增片段长度多态性（AFLP）进行的基因型指纹图谱表明，这三种感染是由单一克隆类型的 B引起的。蜡状的。在其他35名新生儿的气管抽吸样本中发现了相同的菌株。病例对照研究表明，使用Sensormedics通风机进行机械通气是定植和/或感染的危险因素（优势比为9.8; 95％置信区间为1.1至88.2）。前瞻性监测显示， B菌落。蜡状杆菌仅发生在机械通气的新生儿的呼吸道中。 B的流行株。在护理人员的手上和人工通风的气球中发现蜡状蜡样。这些气球的消毒结束了疫情。我们得出结论， B。蜡状杆菌可引起新生儿严重机会性感染的爆发。事实证明，通过AFLP进行分型对确定疫情和分析从环境中回收的菌株以追踪流行病的原因非常有用。

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