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首页> 外文期刊>Journal of Clinical Microbiology >rpoB Mutations in Multidrug-Resistant Strains of Mycobacterium tuberculosis Isolated in Italy
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rpoB Mutations in Multidrug-Resistant Strains of Mycobacterium tuberculosis Isolated in Italy

机译：意大利分离的结核分枝杆菌的多药耐药菌株中的rpoB突变

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Mutations of rpoB associated with rifampin resistance were studied in 37 multidrug-resistant (MDR) clinical strains ofMycobacterium tuberculosis isolated in Italy. At least one mutated codon was found in each MDR strain. It was always a single-base substitution leading to an amino acid change. Nine differentrpoB alleles, three of which had not been reported before, were found. The relative frequencies of specific mutations in this sample were different from those previously reported from different geographical areas, since 22 strains (59.5%) carried the mutated codon TTG in position 531 (Ser→Leu) and 11 (29.7%) had GAC in position 526 (His→Asp).
机译：研究了在意大利分离的37株结核分枝杆菌（EM）的多药耐药（MDR）临床菌株中与rrifampin耐药相关的 rpoB 突变。在每个MDR菌株中发现至少一个突变的密码子。它始终是单碱基取代，导致氨基酸变化。发现了9个不同的 rpoB 等位基因，其中3个以前没有报道。此样本中特定突变的相对频率与先前从不同地理区域报告的相对频率不同，因为22个菌株（59.5％）在531位（Ser→Leu）携带突变的密码子TTG，而11个菌株（29.7％）在位置GAC 526（His→Asp）。

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