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首页> 外文期刊>Journal of Clinical Microbiology >Comparative virulence of human isolates of coagulase-negative staphylococci tested in an infant mouse weight retardation model.
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Comparative virulence of human isolates of coagulase-negative staphylococci tested in an infant mouse weight retardation model.

机译：在婴儿小鼠体重减轻模型中测试的凝固酶阴性葡萄球菌人分离株的比较毒力。

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摘要

Human infections caused by coagulase-negative staphylococci have steadily increased in numbers and severity. Causes may be the use of artificial prostheses, immunocompromising chemotherapy and radiation therapy, and sophisticated surgical techniques, to name a few. Although the infectivity of coagulase-negative staphylococci as a group has been well documented for humans, attempts to study the pathogenesis of infections caused by individual species of coagulase-negative staphylococci have been hampered by the lack of an animal model that is not refractory to infection by these organisms. In the study reported here, a 2-day-old-mouse weight retardation test was used to assay the virulence of 60 clinical and reference strains of coagulase-negative staphylococci. These strains represented eight species of coagulase-negative staphylococci. The most virulent strains were demonstrated to be of the species Staphylococcus haemolyticus, S. saprophyticus, and S. epidermidis. The data further suggest that production of slime is a marker of virulence in S. epidermidis and that intraspecies differences in virulence occur.
机译：由凝固酶阴性葡萄球菌引起的人类感染的数量和严重程度稳步上升。原因可能是人工假体的使用，免疫受损的化学疗法和放射疗法以及复杂的手术技术等。尽管凝血酶阴性葡萄球菌作为一类人群的感染力已有大量文献报道，但是缺乏缺乏耐感染性的动物模型阻碍了研究由个别种类的凝固酶阴性葡萄球菌引起的感染的发病机理的尝试。这些生物。在本文报道的研究中，一项为期2天的小鼠体重延迟测试用于测定60种临床和参考菌株中凝固酶阴性葡萄球菌的毒力。这些菌株代表八种凝固酶阴性葡萄球菌。已证明最具毒性的菌株为溶血葡萄球菌，腐生链球菌和表皮葡萄球菌。数据进一步表明，粘液的产生是表皮葡萄球菌中毒力的标志，并且种内毒力存在差异。

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