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首页> 外文期刊>Journal of Clinical Microbiology >Cross-reactivity of nonspecific treponemal antibody in serologic tests for Lyme disease.
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Cross-reactivity of nonspecific treponemal antibody in serologic tests for Lyme disease.

机译：莱姆病血清学检测中非特异性链状体抗体的交叉反应性。

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Serum samples obtained from 59 persons who had acute necrotizing ulcerative gingivitis, periodontitis, syphilis, or Lyme disease were tested against Treponema phagedenis biotype Reiter, Treponema denticola, Treponema vincentii, and Treponema scoliodontum by indirect fluorescent-antibody staining methods. Although there were positive reactions for sera representing each of these study groups and for 20 (13%) of 156 samples collected from the general population (premarital screening for syphilis), titration endpoints were relatively low (less than or equal to 1:256). Serum samples from 18 persons who had gingivitis or periodontitis but no history of Lyme borreliosis were tested by enzyme-linked immunosorbent assay for antibodies to Borrelia burgdorferi. Of these, five (28%) had immunoglobulin M antibody and four (22%) contained immunoglobulin G antibodies to this spirochete. Adsorption with either sorbent commercially prepared from T. phagedenis biotype Reiter or with washed, whole cells of T. phagedenis biotype Reiter reduced cross-reactivity in the enzyme-linked immunosorbent assay for Lyme borreliosis.
机译：通过间接荧光抗体染色方法，对59例急性坏死性溃疡性牙龈炎，牙周炎，梅毒或莱姆病患者的血清样本进行了针对phadenenis phagedenis生物型Reiter，Denponola denticola，Vrecentema vincentii和Treponema scoliodontum的测试。尽管代表每个研究组的血清都有阳性反应，从普通人群中收集的156个样品中有20个（13％）有阳性反应（婚前梅毒筛查），但滴定终点相对较低（小于或等于1：256） 。通过酶联免疫吸附法检测了18名患有牙龈炎或牙周炎但无莱姆病的病史的人的血清样本，以检测抗伯氏疏螺旋体的抗体。其中，五种（28％）具有针对该螺旋体的免疫球蛋白M抗体，四种（22％）具有针对该螺旋体的免疫球蛋白G抗体。在商业上可从白僵菌生物型Reiter制备的吸附剂或洗涤后的白僵菌生物型Reiter的全细胞进行吸附，从而在酶联免疫吸附试验中降低了莱姆氏疏螺旋体的交叉反应性。

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