Antibody response to serotype-specific and cross-reactive neutralization epitopes on VP4 and VP7 after rotavirus infection or vaccination.

K Taniguchi; T Urasawa; N Kobayashi; M U Ahmed; N Adachi; S Chiba; S Urasawa

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Antibody response to serotype-specific and cross-reactive neutralization epitopes on VP4 and VP7 after rotavirus infection or vaccination.

机译：轮状病毒感染或接种疫苗后，对VP4和VP7上血清型特异性和交叉反应中和表位的抗体反应。

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By using a competitive solid-phase immunoassay with serotype-specific and cross-reactive neutralizing monoclonal antibodies directed at VP4 and VP7, we tested the antibody responses to some neutralization epitopes on VP4 and VP7 in individuals infected or vaccinated with rotavirus. Antibody responses to VP7 epitopes of the infecting serotype of virus were found at a high frequency in both infants and children. In contrast, antibody responses to VP4 and heterotypic VP7 were observed only when the individuals possessed antibodies to any serotype of rotavirus in their acute-phase or prevaccination sera.

机译：通过使用具有针对VP4和VP7的血清型特异性和交叉反应中和性单克隆抗体的竞争性固相免疫测定，我们测试了感染或接种轮状病毒的个体对VP4和VP7的某些中和表位的抗体反应。在婴儿和儿童中都发现了对病毒感染血清型的VP7表位的抗体应答。相反，仅当个体在其急性期或疫苗接种前血清中具有针对任何血清型轮状病毒的抗体时，才观察到对VP4和异型VP7的抗体反应。

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《Journal of Clinical Microbiology》 |1991年第3期|共5页
作者
K Taniguchi; T Urasawa; N Kobayashi; M U Ahmed; N Adachi; S Chiba; S Urasawa;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Antibody response to serotype-specific and cross-reactive neutralization epitopes on VP4 and VP7 after rotavirus infection or vaccination. [J] . K Taniguchi, T Urasawa, N Kobayashi, Journal of Clinical Microbiology . 1991,第3期

机译：轮状病毒感染或接种疫苗后，对VP4和VP7上血清型特异性和交叉反应中和表位的抗体反应。
2. Production of reassortant viruses containing human rotavirus VP4 and SA11 VP7 for measuring neutralizing antibody following natural infection. [J] . R J Gorrell, R F Bishop Clinical and diagnostic laboratory immunology . 1997,第5期

机译：含有人轮状病毒VP4和SA11 VP7的重配病毒的生产，用于在自然感染后测量中和抗体。
3. HUMAN ROTAVIRUS VP4 CONTAINS STRAIN-SPECIFIC, SEROTYPE-SPECIFIC AND CROSS-REACTIVE NEUTRALIZATION SITES [J] . Kirkwood CD, Bishop RF, Coulson BS Archives of virology . 1996,第3a4期

机译：人类轮状病毒VP4包含应变特异性，血清型特异性和交叉反应中性位点
4. Intragastric Administration of Lactobacillus casei Expressing Bovine Rotavirus VP7 Protein Induced Specific Antibody Production [C] . Liu Songmei, Zhang Guanqun, Liu Didi, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：表达牛轮状病毒VP7蛋白的干酪乳杆菌的胃内给药诱导特异性抗体产生
5. Focusing immune response on key neutralizing epitopes of HIV-1 through immune complex vaccination. [D] . Agrawal, Aditi. 2016

机译：通过免疫复合疫苗接种，将免疫应答集中在HIV-1的关键中和表位上。
6. Antibody response to serotype-specific and cross-reactive neutralization epitopes on VP4 and VP7 after rotavirus infection or vaccination. [O] . K Taniguchi, T Urasawa, N Kobayashi, 1991

机译：轮状病毒感染或接种疫苗后对VP4和VP7上血清型特异性和交叉反应中和表位的抗体反应。
7. Production of Reassortant Viruses Containing Human Rotavirus VP4 and SA11 VP7 for Measuring Neutralizing Antibody following Natural Infection [O] . R. J. Gorrell, R. F. Bishop 1998

机译：含有人轮状病毒VP4和SA11 VP7的重新排列病毒的生产，用于测量自然感染后的中和抗体

Antibody response to serotype-specific and cross-reactive neutralization epitopes on VP4 and VP7 after rotavirus infection or vaccination.

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