Restriction fragment length polymorphism analysis using IS6110 as an epidemiological marker in tuberculosis.

I Otal; C Martín; V Vincent-Lévy-Frebault; D Thierry; B Gicquel

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Restriction fragment length polymorphism analysis using IS6110 as an epidemiological marker in tuberculosis.

机译：使用IS6110作为结核病流行病学标记的限制性片段长度多态性分析。

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The mycobacterial insertion sequence IS6110 has been shown to be present in multiple copies in the chromosome of Mycobacterium tuberculosis. IS6110 restriction fragment length polymorphism analysis of strains isolated from patients who developed tuberculosis showed identical patterns over a 2- to 3-year period. In contrast, a high degree of polymorphism was observed between strains of the M. tuberculosis complex isolated from different patients. This study demonstrates that the presence of IS6110 does not induce in vivo major genomic rearrangements over a 2- to 3-year period and confirms its use as a valuable epidemiological marker in tuberculosis.

机译：已经表明分枝杆菌插入序列IS6110在结核分枝杆菌的染色体中以多个拷贝存在。从患肺结核的患者中分离出的菌株的IS6110限制性片段长度多态性分析在2至3年的时间内显示出相同的模式。相反，在从不同患者分离的结核分枝杆菌复合物菌株之间观察到高度的多态性。这项研究表明，IS6110的存在不会在2至3年的时间内诱导体内主要的基因组重排，并证实了其在结核病中作为有价值的流行病学标记物的用途。

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《Journal of Clinical Microbiology》 |1991年第6期|共3页
作者
I Otal; C Martín; V Vincent-Lévy-Frebault; D Thierry; B Gicquel;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Restriction fragment length polymorphism analysis using IS6110 as an epidemiological marker in tuberculosis. [J] . I Otal, C Martín, V Vincent-Lévy-Frebault, Journal of Clinical Microbiology . 1991,第6期

机译：使用IS6110作为结核病流行病学标记的限制性片段长度多态性分析。
2. An IS6110-targeting fluorescent amplified fragment length polymorphism alternative to IS6110 restriction fragment length polymorphism analysis for Mycobacterium tuberculosis DNA fingerprinting. [J] . Thorne N, Evans JT, Smith EG, Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2007,第10期

机译：靶向IS6110的荧光扩增片段长度多态性可替代IS6110限制性片段长度多态性分析，用于结核分枝杆菌DNA指纹分析。
3. Epidemiologic Import of Tuberculosis Cases Whose Isolates Have Similar but Not Identical IS6110 Restriction Fragment Length Polymorphism Patterns [J] . M. D. Cave, Z. H. Yang, R. Stefanova, Journal of Clinical Microbiology . 2005,第3期

机译：具有相似但不相同的IS6110限制性片段长度多态性模式的结核病病例的流行病学意义
4. Parallel application of Variable-Number Tandem-Repeat Markers typing and IS 1245 Restriction Fragment Length Polymorphism fingerprinting of Finnish Mycobacterium avium from human and porcine origins [C] . Tirkkonen Taneli, Pakarinen Jaakko, Rintala Elina, Congress of the International Pig Veterinary Society . 2008

机译：通过人和猪起源于人和猪起源，可变数量串联重复标记键入和是1245个限制片段长度多态性指纹印刷。来自人和猪起源的芬兰分枝杆菌
5. Analysis of chromosomal regions associated with some quantitative traits in barley using restriction fragment length polymorphism (RFLP) markers. [D] . Olufowote, Johnson Oluwole. 1994

机译：使用限制性片段长度多态性（RFLP）标记分析与大麦中一些定量性状相关的染色体区域。
6. Restriction fragment length polymorphism analysis using IS6110 as an epidemiological marker in tuberculosis. [O] . I Otal, C Martín, V Vincent-Lévy-Frebault, 1991

机译：使用IS6110作为结核病流行病学标记的限制性片段长度多态性分析。
7. An IS6110-targeting fluorescent amplified fragment length polymorphism alternative to IS6110 restriction fragment length polymorphism analysis for Mycobacterium tuberculosis DNA fingerprinting [O] . Thorne N., Evans J.T., Smith E.G., 2007

机译：靶向IS6110的荧光扩增片段长度多态性可替代IS6110限制性片段长度多态性分析，用于结核分枝杆菌DNA指纹图谱

Restriction fragment length polymorphism analysis using IS6110 as an epidemiological marker in tuberculosis.

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