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首页> 外文期刊>Journal of Clinical Microbiology >Comparative assessment of Etest for testing susceptibilities of Neisseria gonorrhoeae to penicillin, tetracycline, ceftriaxone, cefotaxime, and ciprofloxacin: investigation using 510(k) review criteria, recommended by the Food and Drug Administration.
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Comparative assessment of Etest for testing susceptibilities of Neisseria gonorrhoeae to penicillin, tetracycline, ceftriaxone, cefotaxime, and ciprofloxacin: investigation using 510(k) review criteria, recommended by the Food and Drug Administration.

机译：Etest对淋病奈瑟氏菌对青霉素，四环素，头孢曲松，头孢噻肟和环丙沙星药敏性的比较评估：采用美国食品药品管理局推荐的510（k）审查标准进行调查。

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We evaluated the ability of the Etest (AB Biodisk, Solna, Sweden) method to accurately and reproducibly determine the antimicrobial susceptibility of Neisseria gonorrhoeae. One hundred gonococcal isolates were used to evaluate the diagnostic performance of the Etest compared with the reference agar dilution method for penicillin, tetracycline, ciprofloxacin, and ceftriaxone. Between 92 and 99% of Etest MIC results for all drugs were within +/- 1 log2 dilution of the reference MIC. According to recommended interpretive criteria, ceftriaxone, cefotaxime, and ciprofloxacin had 100% categorical agreement, while penicillin (86%) and tetracycline (85%) categorical agreement percentages were lower because of the large number of strains that were within 0.5 to 1 log2 dilution of the susceptible or resistant breakpoints. Reproducibility data also demonstrated that the Etest was precise (99.1%) when subjected to replicate testing. On the basis of these data, the Etest method provides an effective, simple alternative to the reference agar dilution method for the direct quantification of N. gonorrhoeae susceptibility.
机译：我们评估了Etest（AB Biodisk，瑞典索尔纳，瑞典）方法准确，可重复地确定淋病奈瑟菌的敏感性的能力。与青霉素，四环素，环丙沙星和头孢曲松的参考琼脂稀释法相比，使用了一百株淋球菌分离株来评估Etest的诊断性能。所有药物的Etest MIC结果的92％至99％在参考MIC的+/- 1 log2稀释范围内。根据推荐的解释性标准，头孢曲松，头孢噻肟和环丙沙星的分类一致性为100％，而青霉素（86％）和四环素（85％）的分类一致性百分比较低，这是因为大量菌株稀释度在0.5至1 log2之间易感或抗性断点。再现性数据还表明，进行重复测试时，Etest准确（99.1％）。根据这些数据，Etest方法可为直接定量淋病奈瑟氏球菌的敏感性提供一种有效，简单的替代参考琼脂稀释法的方法。

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