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首页> 外文期刊>Journal of Clinical Microbiology >Great Diversity of Group A Rotavirus Strains and High Prevalence of Mixed Rotavirus Infections in India
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Great Diversity of Group A Rotavirus Strains and High Prevalence of Mixed Rotavirus Infections in India

机译：印度的A组轮状病毒菌株多样性高，混合轮状病毒感染率高。

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We previously observed a marked diversity of rotavirus strains and a high prevalence of the uncommon serotype G9 in a small survey of rotavirus strains collected from six centers in India. In the present study, we characterized a larger collection of strains from children hospitalized with severe diarrhea in seven Indian cities between 1996 and 1998. A total of 287 strains were G and P genotyped by reverse transcription-PCR, and some were further characterized by electropherotyping and subgrouping. Of the four strains common globally, three were found in only 43% of samples (P[8], G1, 15%; P[4], G2, 22%; P[8], G4, 6%), whereas G9 strains made up 17% of the total. Three different G9 strains were present: a P[8], G9 strain, which displayed the long electropherotype and subgroup II VP6 specificity, and two P[6], G9 strains, one with the long electropherotype and subgroup II specificity and the other with the short electropherotype and subgroup I specificity. Marked diversity was observed among strains collected from different cities and collected over time. Of the 253 strains that were fully typed, 54 (21%) had a mixed G or P genotype. Serotype G2 strains were detected more often in infections caused by single strains than in mixed infections (P < 0.05), whereas serotype G1 strains were found more often in mixed infections than in infections caused by single strains (P < 0.05). The diversity of rotavirus strains and the high prevalence of mixed infections confirm trends reported earlier and help to better characterize the strains of rotavirus circulating in India. Vaccines under development should clearly target G9 strains, and G9 should be included as one of the common global serotypes.
机译：在从印度六个中心收集的轮状病毒株的小型调查中，我们先前观察到轮状病毒株的显着多样性和罕见的G9型血清型的高流行。在本研究中，我们表征了1996年至1998年之间来自印度七个城市的严重腹泻住院儿童的更多菌株。通过逆转录PCR对287株G和P进行基因分型，其中一些通过电分型进一步鉴定和分组。在全球共有的四种菌株中，仅在43％的样品中发现了三株（P [8]，G1，15％; P [4]，G2，22％; P [8]，G4，6％），而G9菌株占总数的17％。存在三种不同的G9菌株：一个显示长电信号型和亚型II VP6特异性的P [8]，G9菌株，和两个P [6]，G9型菌株，一个具有长型电信号和II型亚组特异性，另一个具有短电特征和亚组I特异性。在从不同城市收集并随时间收集的菌株之间观察到明显的多样性。在253个完全分型的菌株中，有54个（21％）具有混合的G或P基因型。在由单一菌株引起的感染中检出的血清型G2菌株比在混合感染中检出率更高（ P <0.05），而在混合感染中发现的血清型G1菌株比由单一菌株引起的检出率更高（< em> P <0.05）。轮状病毒株的多样性和混合感染的高流行证实了先前报道的趋势，并有助于更好地表征在印度流行的轮状病毒株。正在开发的疫苗应明确针对G9菌株，并且G9应该作为常见的全球血清型之一包括在内。

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