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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Epidemiological Analysis of Cryptosporidiumspp. in the United Kingdom: Results of GenotypingCryptosporidium spp. in 1,705 Fecal Samples from Humans and 105 Fecal Samples from Livestock Animals
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Molecular Epidemiological Analysis of Cryptosporidiumspp. in the United Kingdom: Results of GenotypingCryptosporidium spp. in 1,705 Fecal Samples from Humans and 105 Fecal Samples from Livestock Animals

机译：隐孢子虫的分子流行病学分析。在英国：基因分型隐孢子虫属的结果。 1,705份人类粪便样本和105份牲畜粪便样本中

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Cryptosporidium present in 1,705 fecal samples from humans and 105 from livestock animals were analyzed by PCR-restriction fragment length polymorphism of the Cryptosporidium oocyst wall protein. Overall, genotype 1 (human exclusive type) was detected in 37.8% of the samples from humans, genotype 2 (broad host range) was detected in 61.5%, a third genotype designated genotype 3 (Cryptosporidium meleagridis) was detected in 0.3%, and both genotypes 1 and 2 were recovered from 0.4%. All samples from livestock yielded genotype 2. Among 469 patients infected during eight drinking water-related outbreaks, five outbreaks were predominantly due to genotype 1, and three were due to genotype 2. Fifty-four samples were collected from patients involved with five swimming pool-associated outbreaks: two outbreaks were due to genotype 1, one was due to genotype 2, and the remaining two involved both genotypes 1 and 2. Among 26 family outbreaks and 1 children's nursery outbreak (2 to 3 members per group), the same genotype was recovered from the different members of each outbreak: 13 were due to genotype 1, and 14 were due to genotype 2. In eighteen patients reporting contact with animals and/or farms, genotype 1 was recovered from one patient and genotype 2 was recovered from the remaining 17. Among the sporadic cases, there were distinct geographical and temporal variations in the distribution of the genotypes. The spring peak in cases was due to genotype 2. Genotype 1 was significantly more common in patients infected during the late-summer–autumn peak and in those with a history of foreign travel.
机译：通过隐孢子虫卵囊壁蛋白的PCR-限制性片段长度多态性分析了1,705例人类粪便和105头牲畜粪便中的隐孢子虫。总体而言，在人类样本中有37.8％检出了基因型1（人类排他型），在61.5％的样本中检出了基因型2（较宽的宿主范围），第三个基因型称为基因型3（）。基因检出率为0.3％，基因型1和2均从0.4％恢复。牲畜的所有样本均产生基因型2。在8例与饮用水有关的暴发中被感染的469名患者中，有5例主要是由于基因型1，而3例是由于基因型2。 -相关暴发：两次暴发是由于基因型1，一次暴发是由于基因型2，其余两个暴发都涉及基因型1和2。在26个家庭暴发和1个儿童苗圃暴发中（每组2至3名成员），相同从每次暴发的不同成员中恢复了基因型：13位归因于基因型1，14位归因于基因型2。在报告与动物和/或农场有接触的18位患者中，基因型1从一位患者中恢复，基因型2被恢复。从其余的17个中发现。在零星的病例中，基因型的分布存在明显的地理和时间差异。病例中的春季高峰是由于基因型2引起的。基因型1在夏末秋季高峰期感染的患者以及有外游史的患者中更为常见。

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