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首页> 外文期刊>Journal of Clinical Microbiology >Aortic Valve Endocarditis in a Dog Due to Bartonella clarridgeiae
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Aortic Valve Endocarditis in a Dog Due to Bartonella clarridgeiae

机译：狗由于克拉通杆菌引起的主动脉瓣内膜炎

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We report the first documented case of endocarditis associated withBartonella clarridgeiae in any species. B. clarridgeiae was identified as a possible etiological agent of human cat scratch disease. Infective vegetative valvular aortic endocarditis was diagnosed in a 2.5-year-old male neutered boxer. Historically, the dog had been diagnosed with a systolic murmur at 16 months of age and underwent balloon valvuloplasty for severe valvular aortic stenosis. Six months later, the dog was brought to a veterinary hospital with an acute third-degree atrioventricular block and was diagnosed with infective endocarditis. The dog died of cardiopulmonary arrest prior to pacemaker implantation. Necropsy confirmed severe aortic vegetative endocarditis. Blood culture grew a fastidious, gram-negative organism 8 days after being plated. Phenotypic and genotypic characterization of the isolate, including partial sequencing of the citrate synthase (gltA) and 16S rRNA genes indicated that this organism was B. clarridgeiae. DNA extraction from the deformed aortic valve and the healthy pulmonic valve revealed the presence of B. clarridgeiae DNA only from the diseased valve. No Borrelia burgdorferi orEhrlichia sp. DNA could be identified. Using indirect immunofluorescence tests, the dog was seropositive for B. clarridgeiae and had antibodies against Ehrlichia phagocytophila but not against Ehrlichia canis, Ehrlichia ewingii, B. burgdorferi, orCoxiella burnetii.
机译：我们报告了任何物种中与 clartonia clarridgeiae 相关的首例心内膜炎病例。 B。克拉丽科被认为是人类猫抓病的可能病原体。在2.5岁的男性绝育拳击手中诊断出感染性植物性主动脉瓣膜内膜炎。从历史上看，这只狗在16个月大时被诊断出收缩期杂音，并接受了球囊瓣膜成形术治疗严重的主动脉瓣狭窄。六个月后，这只狗被带到急性三级房室传导阻滞的兽医医院，并被诊断出感染性心内膜炎。这只狗死于心脏起搏器植入心脏起搏器之前。尸检证实严重的主动脉植物性心内膜炎。接种后8天，血液培养物生长出一种挑剔的革兰氏阴性菌。分离物的表型和基因型特征，包括柠檬酸合酶（ glt A）和16S rRNA基因的部分测序表明该生物为 B。克拉里奇菌。从变形的主动脉瓣和健康的肺动脉瓣中提取DNA显示存在 B。 clarridgeiae DNA仅来自患病瓣膜。没有 Borrelia burgdorferi 或 Ehrlichia sp。可以鉴定出DNA。使用间接免疫荧光测试，狗对 B呈血清阳性。 clarridgeiae 并具有抗吞噬性埃里希氏菌的抗体，但不抗犬埃里希氏菌，埃里希氏菌，emb的抗体。 burgdorferi 或 burnixii 。

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