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首页> 外文期刊>Journal of Clinical Microbiology >Evaluation of the Subtype Specificity of Monoclonal Antibodies Raised against H1 and H3 Subtypes of Human Influenza A Virus Hemagglutinins
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Evaluation of the Subtype Specificity of Monoclonal Antibodies Raised against H1 and H3 Subtypes of Human Influenza A Virus Hemagglutinins

机译:评估针对人类甲型流感病毒血凝素的H1和H3亚型的单克隆抗体的亚型特异性

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摘要

Three previously described monoclonal antibodies (MAbs) specific for influenza A(H1) hemagglutinins (HA) revealed high sensitivity (98.2 to 99.1%) and specificity (100%) when tested against 245 strains of different subtypes. One of them was included in the World Health Organization's influenza reagent kit for 2001 to 2002. In contrast, two MAbs raised against human influenza A(H3) HA revealed cross-reactivity with viruses of other subtypes.
机译:当针对245种不同亚型的菌株进行测试时,三种针对流感A(H1)血凝素(HA)的特异性单克隆抗体(MAb)显示出高灵敏度(98.2%至99.1%)和特异性(100%)。 2001年至2002年,其中之一被包含在世界卫生组织的流感试剂盒中。相比之下,针对人甲型H3 HA流感病毒产生的两种单克隆抗体显示与其他亚型病毒具有交叉反应性。

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