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首页> 外文期刊>Journal of Clinical Microbiology >Horizontal Transmission of Candida parapsilosis Candidemia in a Neonatal Intensive Care Unit
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Horizontal Transmission of Candida parapsilosis Candidemia in a Neonatal Intensive Care Unit

机译：新生儿重症监护室中副念珠菌念珠菌水平传播

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This report describes the nosocomial acquisition of Candida parapsilosis candidemia by one of the six premature newborns housed in the same room of a neonatal intensive care unit at the Ospedale Santa Chiara, Pisa, Italy. The infant had progeria, a disorder characterized by retarded physical development and progressive senile degeneration. The infant, who was not found to harbor C. parapsilosis at the time of his admission to the intensive care unit, had exhibited symptomatic conjunctivitis before the onset of a severe bloodstream infection. In order to evaluate the source of infection and the route of transmission, two independent molecular typing methods were used to determine the genetic relatedness among the isolates recovered from the newborn, the inanimate hospital environment, hospital personnel, topically and intravenously administered medicaments, and indwelling catheters. Among the isolates collected, only those recovered from the hands of two nurses attending the newborns and from both the conjunctiva and the blood of the infected infant were genetically indistinguishable. Since C. parapsilosis was never recovered from indwelling catheters or from any of the drugs administered to the newborn, we concluded that (i) horizontal transmission of C. parapsilosis occurred through direct interaction between nurses and the newborn and (ii) the conjunctiva was the site through which C. parapsilosis entered the bloodstream. This finding highlights the possibility that a previous C. parapsilosis colonization and/or infection of other body sites may be a predisposing condition for subsequent C. parapsilosis hematogenous dissemination in severely ill newborns.
机译：这份报告描述了在意大利比萨的Ospedale Santa Chiara的新生儿重症监护病房的同一房间里住的六个早产新生儿之一，在医院内获得了 Candida parapsilosis 念珠菌病。婴儿患有早衰症，其特征是身体发育迟缓和进行性老年变性。该婴儿未发现藏有 C。进入重症监护室时发生的副瘫痪，在严重的血液感染开始之前已出现症状性结膜炎。为了评估感染源和传播途径，使用了两种独立的分子分型方法来确定从新生儿中回收的分离株，无生命的医院环境，医院工作人员，局部和静脉内给药的药物以及留置物之间的遗传相关性。导管。在收集的分离株中，只有从两名照料新生儿的护士手中以及从被感染婴儿的结膜和血液中回收的分离株在遗传上无法区分。自 C。从未从留置导管或从用于新生儿的任何药物中恢复到副瘫痪，我们得出结论：（i） C的水平传播。滑膜炎是通过护士与新生儿之间的直接相互作用而发生的;（ii）结膜是 C发生的部位。副瘫痪进入血液。这一发现突显了以前的 C的可能性。寄生虫的定植和/或感染其他身体部位可能是随后 C的诱因。重症新生儿的血源性寄生虫病传播。

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