Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin, as Well as Locally Applied Polyhexamethylene Biguanide

William J. Steinbach; Wiley A. Schell; Jackie L. Miller; John R. Perfect

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Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin, as Well as Locally Applied Polyhexamethylene Biguanide

机译：用伏立康唑和卡泊芬净以及局部应用的聚六亚甲基双胍治疗的具有免疫功能的儿童多发性Sedosporium prolificans骨髓炎

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Scedosporium species are increasingly isolated from immunocompromised and immunocompetent patients. Unfortunately, Scedosporium infections are generally resistant to amphotericin B, and Scedosporium prolificans strains are particularly resistant to the antifungal agents now in use. We report here on an immunocompetent child with S. prolificans-associated osteomyelitis successfully treated with debridement, local irrigation with polyhexamethylene biguanide, and the systemic administration of voriconazole and caspofungin despite poor in vitro activity of voriconazole alone against the isolate. We also review the treatments and outcomes of 28 reported cases of osteomyelitis or septic arthritis caused by Scedosporium species in immunocompetent patients.

机译： Scedosporium 种类越来越多地从免疫功能低下和具有免疫能力的患者中分离出来。不幸的是， Scedosporium 感染通常对两性霉素B具有抗性，而 Scedosporium prolificans 菌株对目前正在使用的抗真菌剂特别有抗性。我们在此报告具有 S免疫力的儿童。尽管单独使用伏立康唑对分离株的体外活性较差，但通过清创术，聚六亚甲基双胍局部冲洗以及全身施用伏立康唑和卡泊芬净成功治疗了与多产仔相关的骨髓炎。我们还回顾了28例免疫功能正常的患者中由 Scedosporium 物种引起的骨髓炎或败血性关节炎的治疗和结果。 展开▼

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《Journal of Clinical Microbiology》 |2003年第8期|共5页

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William J. Steinbach; Wiley A. Schell; Jackie L. Miller; John R. Perfect;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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1. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with a novel agent, hexadecylphospocholine (miltefosine), in combination with terbinafine and voriconazole: a case report. [J] . Kesson AM, Bellemore MC, OMara TJ, Clinical infectious diseases . 2009,第9期

机译：用新型药物十六烷基磷胆碱（米替福辛）与特比萘芬和伏立康唑合用的免疫功能正常儿童的多孢子孢菌骨髓炎。

2. Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with a Novel Agent, Hexadecylphospocholine (Miltefosine), in Combination with Terbinafine and Voriconazole: A Case Report [J] . Alison M. Kesson15 Michael C. Bellemore2 Timothy J. OMara2 David H. Ellis6 and Tania C. Sorrell34 Clinical Infectious Diseases . 2009,第9期

机译：用特比萘芬和伏立康唑联合新型药物六十六磷酸胆碱（Miltefosine）治疗的免疫能力强的儿童产多孢菌（Scedosporium prolificans）骨髓炎：一例病例报告

3. A Case of Scedosporium Prolificans Osteomyelitis in an Immunocompetent Child, Misdiagnosed as Tubercular Osteomyelitis [J] . Monika Matlani, Ravinder Kaur, Shweta Indian journal of dermatology . 2013,第1期

机译：一例免疫功能不良儿童多发性产孢子菌性骨髓炎一例，被误诊为结核性骨髓炎。

4. Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin as Well as Locally Applied Polyhexamethylene Biguanide [O] . William J. Steinbach, Wiley A. Schell, Jackie L. Miller, 2003

机译：用伏立康唑和卡泊芬净以及局部应用的聚六亚甲基双胍治疗的具有免疫功能的儿童多发性Sedosporium prolificans骨髓炎

5. Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin, as Well as Locally Applied Polyhexamethylene Biguanide [O] . Steinbach, William J., Schell, Wiley A., Miller, Jackie L., 2003

机译：用伏立康唑和卡泊芬净以及局部应用的聚六亚甲基双胍治疗的具有免疫功能的儿童多发性Sedosporium prolificans骨髓炎

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2. 聚六亚甲基双胍与双癸基二甲基氯化铵协同作用研究 [J] . 崔玉杰 ,王茜 ,孙克勤 . 医学理论与实践 . 2009,第003期

3. 聚六亚甲基双胍对金鱼嗜水气单胞菌的杀灭及金鱼细菌性疾病的治疗效果 [J] . 冯亚明 ,杨智景 ,顾海龙 . 贵州农业科学 . 2020,第008期

4. 超高效液相色谱-四极杆飞行时间质谱法测定复配消毒产品中聚六亚甲基双胍的含量 [J] . 黄芳 ,邓欣 ,谢淑桐 . 理化检验-化学分册 . 2021,第010期

5. 聚六亚甲基双胍体外抗真菌作用研究 [J] . 谭静文 ,徐红 ,宋金凤 . 中国真菌学杂志 . 2020,第002期

6. 聚六亚甲基双胍盐酸盐的杀菌活性及对空气现场消毒效果的研究 [C] . 苏裕心 ,任哲 ,魏秋华 . 全国消毒论文写作与新进展学术交流会 . 2013

7. 载聚六亚甲基双胍的丝素多孔材料的制备及其抗菌性能 [A] . 张敏 . 2018

1. 聚六亚甲基胍杀菌消毒剂中聚六亚甲基胍含量的检测方法 [P] . 中国专利： CN103163129B . 2014.12.24

2. 一种由单胍中间体合成聚六亚甲基双胍的方法 [P] . 中国专利： CN113773490A . 2021-12-10

3. Synergistic antimicrobial composition, useful e.g. as cosmetic preservative and for treating skin disorders, comprises polyhexamethylene biguanide and distearyldimethylammonium chloride [P] . 外国专利： DE10147186A1 . 2003-04-24

机译：有用的协同抗菌组合物，例如作为化妆品防腐剂和治疗皮肤疾病，包括聚六亚甲基双胍和二硬脂基二甲基氯化铵

4. Polyhexamethylene biguanide composition and method for treating turbulent water [P] . 外国专利： NZ313869A . 2001-01-26

机译：聚六亚甲基双胍组合物和处理湍流水的方法

5. Biocidal compositions comprising polyhexamethylene biguanide and EDTA, and methods for treating commercial and recreational water [P] . 外国专利： US5449658A . 1995-09-12

机译：包含聚六亚甲基双胍和EDTA的杀生物组合物，以及用于处理商业用水和娱乐用水的方法

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Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin, as Well as Locally Applied Polyhexamethylene Biguanide

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