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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Epidemiology of Macrolide-Resistant Isolates of Streptococcus pneumoniae Collected from Blood and Respiratory Specimens in Norway
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Molecular Epidemiology of Macrolide-Resistant Isolates of Streptococcus pneumoniae Collected from Blood and Respiratory Specimens in Norway

机译：挪威从血液和呼吸道标本中收集的耐大环内酯的肺炎链球菌分离株的分子流行病学

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Norway has a low prevalence of antimicrobial resistance, including macrolide-resistant Streptococcus pneumoniae (MRSP). In a nationwide surveillance program, a total of 2,200 S. pneumoniae isolates were collected from blood cultures and respiratory tract specimens. Macrolide resistance was detected in 2.7%. M-type macrolide resistance was found in 60% of resistant isolates, and these were mainly mef(A)-positive, serotype-14 invasive isolates. The erm(B)-encoded macrolide-lincosamide-streptogramin B (MLSB) type dominated among the noninvasive isolates. One strain had an A2058G mutation in the 23S rRNA gene. Coresistance to other antibiotics was seen in 96% of the MLSB-type isolates, whereas 92% of the M-type isolates were susceptible to other commonly used antimicrobial agents. Serotypes 14, 6B, and 19F accounted for 84% of the macrolide-resistant isolates, with serotype 14 alone accounting for 67% of the invasive isolates. A total of 29 different sequence types (STs) were detected by multilocus sequence typing. Twelve STs were previously reported international resistant clones, and 75% of the macrolide-resistant isolates had STs identical or closely related to these clones. Eleven isolates displayed 10 novel STs, and 7/11 of these “Norwegian strains” coexpressed MLSB and tetracycline resistance, indicating the presence of Tn1545. The invasive serotype-14 isolates were all classified as ST9 or single-locus variants of this clone. ST9 is a mef-positive M-type clone, commonly known as England14-9, reported from several European countries. These observations suggest that the import of major international MRSP clones and the local spread of Tn1545 are the major mechanisms involved in the evolution and dissemination of MRSP in Norway.
机译：挪威的抗菌素耐药率很低，包括对大环内酯类耐药的肺炎链球菌（EMSP）。在全国范围内的监视计划中，总共有2200个 S。从血液培养物和呼吸道标本中收集肺炎支原体。检测到大环内酯抗性为2.7％。在60％的耐药菌株中发现了M型大环内酯类药物耐药性，其中主要是 mef （A）阳性，血清型14侵袭性菌株。在非侵入性分离物中，以 erm （B）编码的大环内酯-林可酰胺-链霉菌素B（MLS B ）类型占主导。一株在23S rRNA基因中具有A2058G突变。 96％的MLS B 型分离株对其他抗生素具有抗药性，而92％的MLS分离株对其他常用的抗菌剂敏感。血清型14、6B和19F占大环内酯耐药菌株的84％，仅血清型14占侵袭性菌株的67％。通过多基因座序列分型检测到总共29种不同的序列类型（ST）。先前报道了十二个ST，它们是国际抗性克隆，而对大环内酯类耐药的分离株中有75％的ST与这些克隆相同或密切相关。 11个分离株显示10个新的ST，这些“挪威菌株”中的7/11共表达MLS B 和四环素抗性，表明存在Tn 1545 。侵袭性血清型14分离株均归为该克隆的ST9或单基因座变异体。 ST9是 mef 阳性的M型克隆，通常被称为England 14 -9，据欧洲几个国家报道。这些观察结果表明，主要的国际MRSP克隆的进口和Tn 1545 的本地传播是挪威MRSP进化和传播的主要机制。

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