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首页> 外文期刊>Journal of Clinical Microbiology >Antimicrobial Susceptibility Patterns and Staphylococcal Cassette Chromosome mec Types of, as Well as Panton-Valentine Leukocidin Occurrence among, Methicillin-Resistant Staphylococcus aureus Isolates from Children and Adults in Middle Tennessee
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Antimicrobial Susceptibility Patterns and Staphylococcal Cassette Chromosome mec Types of, as Well as Panton-Valentine Leukocidin Occurrence among, Methicillin-Resistant Staphylococcus aureus Isolates from Children and Adults in Middle Tennessee

机译：田纳西州中部儿童和成年人的耐甲氧西林金黄色葡萄球菌分离株的抗菌药敏模式和金黄色葡萄球菌盒型mcc类型以及Panton-Valentine Leukocidin的发生

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Antimicrobial susceptibility patterns, Panton-Valentine leukocidin (PVL) occurrence, and staphylococcal cassette chromosome mec (SCCmec) types in methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from children and adults at Vanderbilt University Medical Center during a 12-month period were evaluated. A total of 1,315 MRSA isolates were collected, of which 748 (36.7%) were recovered from children. Among all isolates, 448 (34.1%) were SCCmec-II, and 847 (64.4%) were SCCmec-IV. More SCCmec-IV isolates were recovered from children than SCCmec-II isolates (424 [50.1%] versus 50 [11.2%]; odds ration [OR] = 7.98; P < 0.000001). The PVL gene was detected in 93.6% of SCCmec-IV isolates, in contrast to 0.2% in SCCmec-II isolates. Within SCCmec-IV isolates, a statistically higher PVL occurrence was noticed in children (98.1%) than in adults (89.1%) (OR = 6.34; P < 0.000001). Overall, SCCmec-II strains showed greater resistance than SCCmec-IV strains to clindamycin, erythromycin, levofloxacin, gentamicin, rifampin, minocycline, and trimethoprim-sulfamethoxazole. Both SCCmec-II and SCCmec-IV strains recovered from adults were more resistant to these antibiotics than those recovered from children. SCCmec-II strains were predominantly recovered from the respiratory tract, whereas SCCmec-IV strains were predominantly recovered from skin, soft tissue, abscesses, and surgical wounds. These data indicate that SCCmec-IV MRSA isolates frequently infect children in middle Tennessee and are likely to harbor the PVL gene.
机译：耐甲氧西林的金黄色葡萄球菌的抗生素敏感性模式，潘顿-华伦白蛋白（PVL）发生和葡萄球菌盒染色体 mec （SCC mec ）类型对范德比尔特大学医学中心在12个月内从儿童和成人中分离出的（MRSA）菌株进行了评估。总共收集了1,315份MRSA分离株，其中748份（36.7％）从儿童中回收。在所有分离株中，SCC mec -II为448（34.1％），SCC mec -IV为847（64.4％）。从儿童中回收的SCC mec -IV分离株比SCC mec -II分离株多（424 [50.1％]对50 [11.2％];优势比[OR] = 7.98 ; P <0.000001）。在93.6％的SCC mec -IV分离株中检测到PVL基因，而在SCC mec -II分离株中检测到0.2％。在SCC mec -IV分离物中，儿童（98.1％）的PVL发生率显着高于成人（89.1％）（OR = 6.34; P <0.000001） 。总体而言，SCC mec -II菌株对克林霉素，红霉素，左氧氟沙星，庆大霉素，利福平，米诺环素和甲氧苄啶-磺胺甲基异恶唑的抗药性均高于SCC mec -IV菌株。从成人中回收的SCC mec -II和SCC mec -IV菌株对这些抗生素的抵抗力均比从儿童中回收的菌株高。 SCC mec -II菌株主要从呼吸道恢复，而SCC mec -IV菌株主要从皮肤，软组织，脓肿和手术伤口恢复。这些数据表明，SCC mec -IV MRSA分离株经常感染田纳西州中部的儿童，并且可能带有PVL基因。

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