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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Diversity of Rabies Viruses Associated with Bats in Mexico and Other Countries of the Americas
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Molecular Diversity of Rabies Viruses Associated with Bats in Mexico and Other Countries of the Americas

机译：墨西哥和其他美洲国家与蝙蝠相关的狂犬病狂犬病毒的分子多样性

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Bat rabies and its transmission to humans and other species in Mexico were investigated. Eighty-nine samples obtained from rabid livestock, cats, dogs, and humans in Mexico were studied by antigenic typing and partial sequence analysis. Samples were further compared with enzootic rabies associated with different species of bats in the Americas. Patterns of nucleotide variation allowed the definition of at least 20 monophyletic clusters associated with 9 or more different bat species. Several lineages associated with distinctive antigenic patterns were found in rabies viruses related to rabies in vampire bats in Mexico. Vampire bat rabies virus lineages associated with antigenic variant 3 are widely spread from Mexico to South America, suggesting these lineages as the most likely ancestors of vampire bat rabies and the ones that have been moved by vampire bat populations throughout the Americas. Rabies viruses related to Lasiurus cinereus, Histiotus montanus, and some other not yet identified species of the genus Lasiurus were found circulating in Mexico. Long-range dissemination patterns of rabies are not necessarily associated with migratory bat species, as in the case of rabies in Desmodus rotundus and Histiotus montanus. Human rabies was associated with vampire bat transmission in most cases, and in one case, rabies transmission from free-tailed bats was inferred. The occurrence of rabies spillover from bats to domestic animals was also demonstrated. Genetic typing of rabies viruses allowed us to distinguish trends of disease dissemination and to address, in a preliminary fashion, aspects of the complex evolution of rabies viruses in different host-reservoir species.
机译：对蝙蝠狂犬病及其在墨西哥向人类和其他物种的传播进行了调查。通过抗原分型和部分序列分析研究了来自墨西哥狂犬病牲畜，猫，狗和人的89个样品。进一步将样品与美洲不同种类蝙蝠相关的狂犬病狂犬病进行了比较。核苷酸变异的模式允许定义至少20个与9种或更多不同蝙蝠物种相关的单系统簇。在墨西哥的吸血蝙蝠中，与狂犬病有关的狂犬病毒中发现了几种与独特的抗原模式有关的谱系。与抗原变异体3相关的吸血蝙蝠狂犬病毒谱系从墨西哥广泛传播到南美，这表明这些血统是吸血蝙蝠狂犬病最有可能的祖先，并且是整个美洲的吸血蝙蝠人群所迁移的祖先。在墨西哥发现了与 Lasiurus cinereus ， Histiotus montanus 以及其他尚未鉴定的 Lasiurus 属有关的狂犬病病毒。狂犬病的远程传播模式不一定与迁徙蝙蝠物种有关，例如 Desmodus rotundus 和 Histiotus montanus 中的狂犬病。在大多数情况下，人类狂犬病与吸血蝙蝠的传播有关，在一种情况下，可以推断出从无尾蝙蝠传播的狂犬病。还证明了狂犬病从蝙蝠溢出到家畜的情况。狂犬病病毒的基因分型使我们能够区分疾病传播的趋势，并以初步的方式解决了狂犬病病毒在不同宿主宿主物种中复杂进化的各个方面。

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