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首页> 外文期刊>Journal of Clinical Microbiology >Statistical Analyses of Correlation between Fluconazole MICs for Candida spp. Assessed by Standard Methods Set Forth by the European Committee on Antimicrobial Susceptibility Testing (E.Dis. 7.1) and CLSI (M27-A2)
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Statistical Analyses of Correlation between Fluconazole MICs for Candida spp. Assessed by Standard Methods Set Forth by the European Committee on Antimicrobial Susceptibility Testing (E.Dis. 7.1) and CLSI (M27-A2)

机译：念珠菌氟康唑MICs之间相关性的统计分析。由欧洲抗菌药物敏感性测试委员会（E.Dis。7.1）和CLSI（M27-A2）制定的标准方法进行评估

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The European Committee on Antimicrobial Susceptibility Testing (EUCAST) Subcommittee on Antifungal Susceptibility Testing recently published a standard for determining the susceptibility of fermentative yeasts to antifungals. From the beginning, the EUCAST and its North American counterpart, the CLSI, decided to work together in order to establish common standards. As part of this exercise, the susceptibility of a set of 475 yeast isolates was tested by both standards. The intraclass correlation coefficient and the equations defining the linear regression between both methods were estimated. Both methods produced very similar results, with an intraclass correlation coefficient of 0.954 (0.945 to 0.962), although linear regression analysis shows that the EUCAST standard resulted in slightly lower MICs. There were only eight isolates showing at least four twofold dilution MIC differences between both standards. After 24 h of incubation, the MICs obtained by the CLSI method were equivalent to those obtained by the EUCAST standard. In summary, both methods produce very similar MICs, indicating that methodology does not pose any obstacle to obtaining uniform standards for antifungal susceptibility testing of yeasts.
机译：欧洲抗微生物药敏试验委员会（EUCAST）抗真菌药敏试验小组委员会最近发布了测定发酵酵母对抗真菌药敏感性的标准。从一开始，EUCAST及其北美同行CLSI就决定共同努力以建立通用标准。作为此练习的一部分，通过两种标准测试了一组475种酵母菌的敏感性。估计了类内相关系数和定义这两种方法之间线性回归的方程式。两种方法均产生非常相似的结果，组内相关系数为0.954（0.945至0.962），尽管线性回归分析表明EUCAST标准导致MIC稍低。只有八个分离物在两个标准品之间显示出至少四个两倍的稀释MIC差异。孵育24小时后，通过CLSI方法获得的MIC与通过EUCAST标准获得的MIC相当。总而言之，两种方法均产生非常相似的MIC，这表明该方法对获得酵母抗真菌药敏试验的统一标准没有任何障碍。

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