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首页> 外文期刊>Journal of Clinical Microbiology >Molecular epidemiology of tuberculosis in Denmark in 1992.
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Molecular epidemiology of tuberculosis in Denmark in 1992.

机译：1992年丹麦结核病的分子流行病学。

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The incidence of tuberculosis (TB) is increasing all over the world, including in countries with a high standard of living and good social security. Denmark represents such a region. Furthermore, it is a small country (5 million inhabitants) with a long tradition in TB control, including a centralization of the bacteriological diagnostic facility. The present study was intended to analyze the transmission of Mycobacterium tuberculosis in a country in which TB has low endemicity by a combination of conventional epidemiological approaches and DNA fingerprinting techniques, whereby individual bacterial strains can be traced. M. tuberculosis isolates from 92% of all new cases of bacteriologically verified TB in Denmark during 1992 were subjected to IS6110 DNA fingerprinting to visualize the DNA restriction fragment length polymorphism (RFLP) patterns of the isolated strains. The data obtained from the RFLP analyses were interpreted by using demographic data, such as age, sex, ethnicity, and residence, for the patients. The risk factors among the patients for being part of an active chain of transmission, as opposed to demonstrating reactivation of a previously acquired latent infection, were estimated by statistical analyses. The magnitude of TB transmission in 1992 in Denmark was determined, and transmitted infections were shown to comprise at least one quarter of the total number of cases. Almost half of the TB cases involved patients of foreign origin. However, most of these isolates showed unique DNA fingerprint patterns and were rarely part of an active chain of transmission. The major chains of recent transmission were localized to distinct geographical regions in the country. TB is frequent among immigrants, especially from Asia and Africa, but it is apparently readily suspected, diagnosed, and treated by the health care system. Danish patients with pulmonary symptoms are not primarily suspected to have TB and, therefore, play an important role in recent TB transmission in Denmark.
机译：全世界，包括生活水平高和社会保障良好的国家，结核病的发病率都在增加。丹麦就是这样一个地区。此外，这是一个小国（500万居民），在结核病控制方面拥有悠久的传统，包括对细菌诊断设施的集中管理。本研究旨在通过常规流行病学方法和DNA指纹技术相结合的方法，在结核病流行率较低的国家中分析结核分枝杆菌的传播情况，从而可以追踪单个细菌菌株。对1992年丹麦细菌学证实的所有新病例中92％的结核分枝杆菌进行了IS6110 DNA指纹分析，以可视化分离株的DNA限制性片段长度多态性（RFLP）模式。通过使用人口统计数据（例如年龄，性别，种族和居住地）来解释从RFLP分析获得的数据。通过统计分析估计了患者中属于主动传播链的一部分的危险因素，这与证明先前获得的潜伏感染重新激活相反。确定了1992年丹麦的结核病传播程度，已证明传播的感染至少占病例总数的四分之一。几乎一半的结核病例涉及外来患者。但是，大多数这些分离株显示出独特的DNA指纹图谱，并且很少是主动传播链的一部分。最近传播的主要链被定位在该国不同的地理区域。结核病在移民中很常见，特别是在亚洲和非洲，但显然很容易被卫生保健系统怀疑，诊断和治疗。最初没有怀疑具有肺部症状的丹麦患者患有结核病，因此，在丹麦最近的结核病传播中起着重要作用。

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