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首页> 外文期刊>Journal of Clinical Microbiology >Most Enterobacter aerogenes Strains in France Belong to a Prevalent Clone
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Most Enterobacter aerogenes Strains in France Belong to a Prevalent Clone

机译：法国大多数产气肠杆菌菌株都属于普遍克隆

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The aim of this study was to determine the distribution in France of the Enterobacter aerogenes prevalent clone isolated in the hospitals of the Marseille area (A. Davin-Regli, D. Monnet, P. Saux, C. Bosi, R. Charrel, A. Barthelemy, and C. Bollet, J. Clin. Microbiol. 34:1474–1480, 1996). A total of 123 E. aerogenes isolates were collected from 23 hospital laboratories and analyzed by random amplification of polymorphic DNA and enterobacterial repetitive intergenic consensus-PCR to determine their epidemiological relatedness. Molecular typing revealed that 21 of the 23 laboratories had isolated this prevalent clone harboring the plasmid encoding for extended-spectrum β-lactamase of the TEM-24 type. Most isolates were susceptible only to imipenem and gentamicin. Their dissemination seems to be clonal and was probably the result of the general use of broad-spectrum cephalosporins and quinolones. Four isolates showed an alteration of their outer membrane proteins, causing decrease of susceptibility to third-generation cephalosporins and imipenem and leading to the critical situation of having no alternative therapeutic. The large dissemination of the E. aerogenesprevalent clone probably results from its good adaptation to the antibiotics administered in France and the hospital environment, particularly in intensive care units.
机译：这项研究的目的是确定在马赛地区的医院中分离出的产气肠杆菌流行克隆在法国的分布（A.Davin-Regli，D.Monnet，P.Saux，C. Bosi，R。Charrel，A。Barthelemy和C.Bollet，J。Clin。Microbiol。34：1474-1480，1996年）。总共123个 E。从医院的23个实验室中分离出气源性细菌，并通过多态性DNA的随机扩增和肠细菌重复基因间共有-PCR进行分析，以确定它们的流行病学相关性。分子分型显示，这23个实验室中有21个已分离出该普遍克隆，该克隆带有编码TEM-24型超广谱β-内酰胺酶的质粒。大多数分离株仅对亚胺培南和庆大霉素敏感。它们的传播似乎是无性的，并且可能是广谱头孢菌素和喹诺酮类药物普遍使用的结果。四个分离株显示其外膜蛋白发生了改变，导致对第三代头孢菌素和亚胺培南的敏感性降低，并导致无法替代治疗的危急情况。 E的广泛传播。产气菌普遍存在的克隆可能是由于其对法国和医院环境（尤其是重症监护病房）中使用的抗生素的良好适应性而产生的。

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