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首页> 外文期刊>Journal of Clinical Microbiology >Nosocomial Fungemia Due to Exophiala jeanselmei var.jeanselmei and a Rhinocladiella Species: Newly Described Causes of Bloodstream Infection
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Nosocomial Fungemia Due to Exophiala jeanselmei var.jeanselmei and a Rhinocladiella Species: Newly Described Causes of Bloodstream Infection

机译：引起外来细菌的医院真菌病jeelselmei var.jeanselmei和Rhinocladiella种：新描述的血液感染原因

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Fungi have become increasingly important causes of nosocomial bloodstream infections. The major cause of nosocomial fungemia has beenCandida spp, but increasingly molds and other yeasts have caused disease. Exophiala jeanselmei and members of the genus Rhinocladiella are dematiaceous moulds, which have been infrequently associated with systemic infection and have not been described as causes of fungemia. In this paper, the occurrence of 23 cases of fungemia due to these organisms over a 10-month period is reported and the clinical characteristics of patients and outcomes are described. The majority of patients were immunosuppressed; 21 of 23 (91%) had received blood products and 78% had a central venous catheter. All patients had at least one manifestation of fever, but only one patient had signs or symptoms suggesting deep-seated infection. Antifungal therapy was given to 19 of the 23 patients; of those who did not receive therapy, 3 died prior to the culture result and 1 had been discharged without therapy. Antifungal susceptibility of the organisms showed activity of amphotericin B, itraconazole, and the new triazole antifungals voriconazole and posaconazole. E. jeanselmei and Rhinocladiella species are potential causes of nosocomial fungemia and may be associated with systemic infection.
机译：真菌已成为医院血液感染日益重要的原因。医院真菌感染的主要原因是 Candida spp，但是越来越多的霉菌和其他酵母菌已经引起疾病。 Exophiala Jeanselmei 和 Rhinocladiella 属是皮损霉菌，很少与全身感染相关，也没有被描述为真菌病的病因。在本文中，报告了在10个月的时间内因这些微生物而发生的23例真菌病的发生，并描述了患者的临床特征和结局。大多数患者被免疫抑制。 23人中有21人（91％）接受了血液制品治疗，而78％的患者接受了中央静脉导管。所有患者至少有一种发烧表现，但只有一名患者的症状或体征提示深层感染。 23例患者中有19例接受了抗真菌治疗。在未接受治疗的患者中，有3例在培养结果之前死亡，另有1例未经治疗就出院。该生物体的抗真菌药性显示出两性霉素B，伊曲康唑和新的三唑抗真菌药伏立康唑和泊沙康唑的活性。 E。 Jeanselmei 和 Rhinocladiella 物种是医院内真菌病的潜在原因，可能与全身感染有关。

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