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首页> 外文期刊>Journal of Clinical Microbiology >Differences in Virulence Factors among Clinical Isolates of Escherichia coli Causing Cystitis and Pyelonephritis in Women and Prostatitis in Men
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Differences in Virulence Factors among Clinical Isolates of Escherichia coli Causing Cystitis and Pyelonephritis in Women and Prostatitis in Men

机译：女性引起膀胱炎和肾盂肾炎的男性临床分离株和男性前列腺炎的毒力因子之间的差异

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摘要

Differences in the presence of nine urovirulence factors among clinical isolates of Escherichia coli causing cystitis and pyelonephritis in women and prostatitis in men have been studied. Hemolysin and necrotizing factor type 1 occur significantly more frequently among isolates causing prostatitis than among those causing cystitis (P < 0.0001) or pyelonephritis (P < 0.005). Moreover, the papGIII gene occurred more frequently in E. coli isolates associated with prostatitis (27%) than in those associated with pyelonephritis (9%) (P < 0.05). Genes encoding aerobactin and PapC occurred significantly less frequently in isolates causing cystitis than in those causing prostatitis (P < 0.01 and P < 0.0001, respectively) and pyelonephritis (P < 0.01 and P < 0.0001, respectively). No differences in the presence of Sat or type 1 fimbriae were found. Finally, AAFII and Bfp fimbriae are no longer considered uropathogenic virulence factors since they were not found in any of the strains analyzed. Overall, the results showed that clinical isolates producing prostatitis need greater virulence than isolates producing pyelonephritis in women or, in particular, cystitis in women (P < 0.05). Overall, the results suggest that clinical isolates producing prostatitis are more virulent that those producing pyelonephritis or cystitis in women.
机译：研究了导致女性膀胱炎和肾盂肾炎和男性前列腺炎的大肠杆菌临床分离物中存在的九种尿毒力因子的差异。在引起前列腺炎的分离株中，溶血素和坏死因子1型的发生率明显高于引起膀胱炎（ P <0.0001）或肾盂肾炎（ P <0.005）的分离株。此外， papGIII 基因在 E中的发生频率更高。与前列腺炎相关的大肠杆菌分离株占27％，而与肾盂肾炎相关的分离株占9％（ P <0.05）。与引起前列腺炎的细菌（分别 P <0.01和 P <0.0001）和肾盂肾炎（ P <0.01和 P <0.0001）。在Sat或1型菌毛的存在下未发现差异。最后，AAFII和Bfp菌毛不再被认为是尿路致病性毒力因子，因为在所分析的任何菌株中均未发现它们。总体而言，结果表明，与女性，尤其是女性膀胱炎相比，临床上产生前列腺炎的菌株比产生肾盂肾炎的菌株具有更高的毒力（ P <0.05）。总体而言，结果表明，在女性中，产生前列腺炎的临床分离株比产生肾盂肾炎或膀胱炎的分离株更具毒性。

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