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首页> 外文期刊>Journal of Clinical Microbiology >Subdivision of Burkholderia pseudomallei ribotypes into multiple types by random amplified polymorphic DNA analysis provides new insights into epidemiology.
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Subdivision of Burkholderia pseudomallei ribotypes into multiple types by random amplified polymorphic DNA analysis provides new insights into epidemiology.

机译：通过随机扩增的多态性DNA分析将伯克霍尔德菌假Mallei核型细分为多种类型，为流行病学提供了新的见解。

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摘要

Ribotyping has previously been used for epidemiological studies of Burkholderia pseudomallei (previously Pseudomonas pseudomallei). We show here that random amplified polymorphic DNA (RAPD) analysis allows subdivision of strains of the same ribotype. With five different primers, no two epidemiologically unrelated isolates of any single ribotype in this study of 102 isolates from humans, goats, cats, and soil had identical RAPD patterns. Conversely, RAPD analysis showed clonality for isolates from each of two animal outbreaks of melioidosis and from a nontropical focus of animal and human melioidosis spanning 25 years. Some soil isolates were identical to epidemiologically related animal and human isolates as determined by RAPD typing. There was no evidence that the clinical outcome of melioidosis was related to RAPD patterns.
机译：核型分型以前曾被用于假伯克霍尔德氏菌（以前称为假单胞菌）的流行病学研究。我们在这里显示，随机扩增多态性DNA（RAPD）分析允许细分相同核糖型的菌株。使用五种不同的引物，在这项针对人类，山羊，猫和土壤的102个分离株的研究中，没有两个与任何单一核糖型无关的流行病学无关分离株具有相同的RAPD模式。相反，RAPD分析显示了两个动物突触病暴发的分离株以及跨越25年的动物和人类突触病的非热带病重点。根据RAPD分型，某些土壤分离株与流行病学相关的动物和人类分离株相同。没有证据表明类胡突病的临床结局与RAPD模式有关。

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