Acquisition of High-Level Mupirocin Resistance and Its Fitness Cost among Methicillin-Resistant Staphylococcus aureus Strains with Low-Level Mupirocin Resistance

Kanokporn Mongkolrattanothai; Lisa Pumfrey; Peggy Mankin; Barry M. Gray

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Acquisition of High-Level Mupirocin Resistance and Its Fitness Cost among Methicillin-Resistant Staphylococcus aureus Strains with Low-Level Mupirocin Resistance

机译：耐甲氧西林金黄色葡萄球菌菌株对莫匹罗星耐药的高水平对莫匹罗星的耐药性及其适应性成本

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We investigated whether methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) isolates with low-level mupirocin resistance can serve as recipients of a pSK41-like plasmid conferring high-level mupirocin resistance without substantial fitness cost. Our results suggest that acquisition of the plasmid conferring high-level mupirocin resistance was not necessarily associated with fitness cost in some MRSA recipients with low-level mupirocin resistance.

机译：我们调查了耐甲氧西林（美西林）的金黄色葡萄球菌（MRSA）菌株对莫匹罗星的抗药性较低，是否可以作为pSK41样质粒的受体，而对质粒却具有较高的莫匹罗星的抗药性，而又不花费大量的健身费用。我们的结果表明，获得具有高水平莫匹罗星抗性的质粒不一定与某些具有低水平莫匹罗星抗性的MRSA接受者的适应性成本相关。

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《Journal of Clinical Microbiology》 |2009年第12期|共3页
作者
Kanokporn Mongkolrattanothai; Lisa Pumfrey; Peggy Mankin; Barry M. Gray;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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6. Acquisition of High-Level Mupirocin Resistance and Its Fitness Cost among Methicillin-Resistant Staphylococcus aureus Strains with Low-Level Mupirocin Resistance [O] . Kanokporn Mongkolrattanothai, Lisa Pumfrey, Peggy Mankin, 2009

机译：耐甲氧西林金黄色葡萄球菌菌株对莫匹罗星耐药的高水平对莫匹罗星的耐药性及其适应性成本
7. Acquisition of High-Level Mupirocin Resistance and Its Fitness Cost among Methicillin-Resistant Staphylococcus aureus Strains with Low-Level Mupirocin Resistance ▿ [O] . Mongkolrattanothai, Kanokporn, Pumfrey, Lisa, Mankin, Peggy, 2009

机译：耐甲氧西林金黄色葡萄球菌菌株对莫匹罗星耐药的高水平对莫匹罗星的耐药性及其适应性成本▿

Acquisition of High-Level Mupirocin Resistance and Its Fitness Cost among Methicillin-Resistant Staphylococcus aureus Strains with Low-Level Mupirocin Resistance

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