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首页> 外文期刊>Journal of Clinical Microbiology >Severe Acquired Toxoplasmosis in Immunocompetent Adult Patients in French Guiana
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Severe Acquired Toxoplasmosis in Immunocompetent Adult Patients in French Guiana

机译：在法属圭亚那具有免疫能力的成年患者中严重获得性弓形虫病

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摘要

The most common presentation of symptomatic postnatally acquired toxoplasmosis in immunocompetent patients is painless cervical adenopathy. Acute visceral manifestations are associated in rare cases. We report 16 cases of severe primary toxoplasmosis diagnosed in French Guiana during a 6.5-year period. All of the subjects were immunocompetent adults hospitalized with clinical presentations consisting of a marked, nonspecific infectious syndrome accompanied by an altered general status with at least one visceral localization, mainly pulmonary involvement (14 cases). Acute toxoplasmosis was diagnosed according to the results of serological tests suggestive of recent primary infection and the absence of an alternative etiology. Recovery was rapid following specific antitoxoplasmosis treatment. Thirteen of the 16 patients had consumed game in the 2 weeks before the onset of the symptoms, and in eight cases the game was considered to have been undercooked. Toxoplasma strains, which were virulent in mice, were isolated from three patients. Microsatellite analysis showed that all of these isolates exhibited an atypical multilocus genotype, with one allele found only for isolates of this region.
机译：有免疫能力的患者中症状性产后获得性弓形虫病最常见的表现是无痛性宫颈腺病。急性内脏表现很少见。我们报告了在6.5年内在法属圭亚那诊断出的16例严重原发性弓形虫病病例。所有受试者均为有免疫能力的成年人，其住院表现为临床表现，包括明显的非特异性感染综合征，伴有一般状况改变，至少有一个内脏部位，主要是肺部受累（14例）。根据血清学检查结果诊断为急性弓形虫病，提示最近的原发感染且没有其他病因。经过特殊的抗弓形虫病治疗后恢复很快。 16名患者中有13名在症状发作前的2周内已食用游戏，而在8例中，游戏被认为未煮熟。从三名患者中分离出有毒力的弓形虫菌株。微卫星分析表明，所有这些分离株均表现出非典型的多基因座基因型，仅在该区域的分离株中发现了一个等位基因。

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