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首页> 外文期刊>Journal of Clinical Microbiology >Survey of emm Gene Sequences from Pharyngeal Streptococcus pyogenes Isolates Collected in Spain and Their Relationship with Erythromycin Susceptibility
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Survey of emm Gene Sequences from Pharyngeal Streptococcus pyogenes Isolates Collected in Spain and Their Relationship with Erythromycin Susceptibility

机译：在西班牙收集的化脓性咽链球菌分离物的emm基因序列及其与红霉素敏感性的关系

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We conducted a nationwide survey of the variable 5′ emm (M protein gene) sequences from 614 pharyngeal Streptococcus pyogenes isolates susceptible (299 isolates) and resistant (315 isolates) to erythromycin that were isolated in Spain from 1996 to 1999. Almost 98% of these isolates had emm sequences in agreement with previously recorded M antigen association. We only identified a new 5′ emm sequence in 17 isolates. Nine different emm types accounted for 85% of the S. pyogenes isolates susceptible to erythromycin. By contrast, only 3 emm types accounted for 70% of the erythromycin-resistant isolates. Further characterization of these isolates by ribotyping and pulsed-field gel electrophoresis indicated that high frequency of erythromycin resistance in Spain is due to few clones.
机译：我们在全国范围内对614例化脓性链球菌化脓性链球菌（em）的5' emm （M蛋白基因）可变序列进行了调查，这些菌株对红霉素敏感（299株）和耐药（315株）从1996年至1999年在西班牙分离到的这些抗原。这些分离株中几乎98％的序列具有 emm 序列，与先前记录的M抗原结合一致。我们仅在17个分离物中鉴定出一个新的5' emm 序列。九种不同的 emm 类型占 S的85％。化脓菌分离株对红霉素敏感。相比之下，只有三种 emm 类型占抗红霉素菌株的70％。通过核糖分型法和脉冲场凝胶电泳对这些分离株进行进一步表征，表明西班牙的红霉素耐药性高是由于克隆少。

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