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首页> 外文期刊>Journal of Clinical Microbiology >Assessing the Risk of Laboratory-Acquired Meningococcal Disease
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Assessing the Risk of Laboratory-Acquired Meningococcal Disease

机译：评估实验室获得性脑膜炎球菌疾病的风险

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Neisseria meningitidis is infrequently reported as a laboratory-acquired infection. Prompted by two cases in the United States in 2000, we assessed this risk among laboratorians. We identified cases of meningococcal disease that were possibly acquired or suspected of being acquired in a laboratory by placing an information request on e-mail discussion groups of infectious disease, microbiology, and infection control professional organizations. A probable case of laboratory-acquired meningococcal disease was defined as illness meeting the case definition for meningococcal disease in a laboratorian who had occupational exposure to an N. meningitidis isolate of the same serogroup within 14 days of illness onset. Sixteen cases of probable laboratory-acquired meningococcal disease occurring worldwide between 1985 and 2001 were identified, including six U.S. cases between 1996 and 2000. Nine cases (56%) were serogroup B; seven (44%) were serogroup C. Eight cases (50%) were fatal. All cases occurred among clinical microbiologists. In 15 cases (94%), isolate manipulation was performed without respiratory protection. We estimated that an average of three microbiologists are exposed to the 3,000 meningococcal isolates seen in U.S. laboratories yearly and calculated an attack rate of 13/100,000 microbiologists between 1996 and 2001, compared to 0.2/100,000 among U.S. adults in general. The rate and case/fatality ratio of meningococcal disease among microbiologists are higher than those in the general U.S. population. Specific risk factors for laboratory-acquired infection are likely associated with exposure to droplets or aerosols containing N. meningitidis. Prevention should focus on the implementation of class II biological safety cabinets or additional respiratory protection during manipulation of suspected meningococcal isolates.
机译：脑膜炎奈瑟菌（emisseria meningitidis）很少报告为实验室获得性感染。在2000年美国的两起病例的提示下，我们评估了实验室医生中的这种风险。通过将信息请求放在传染病，微生物学和感染控制专业组织的电子邮件讨论组中，我们确定了可能在实验室中获得或怀疑在实验室中获得的脑膜炎球菌病病例。实验室获得性脑膜炎球菌疾病的可能病例定义为符合职业性暴露于 N的实验室工作人员脑膜炎球菌疾病病例定义的疾病。发病后14天内，同一血清群的脑膜炎双球菌分离株。确定了1985年至2001年全球范围内发生的16例实验室获得性脑膜炎球菌病病例，其中1996年至2000年之间有6例美国病例。B血清型9例（56％）;血清组C有7例（44％）。致命8例（50％）。所有病例均发生在临床微生物学家中。 15例（94％）患者在没有呼吸保护的情况下进行了隔离操作。我们估计，每年平均有三名微生物学家接触美国实验室中发现的3,000种脑膜炎球菌，并计算出1996年至2001年间微生物学家的攻击率为13 / 100,000，而美国成年人中的平均发病率为0.2 / 100,000。在微生物学家中，脑膜炎球菌病的发病率和病死率均高于美国一般人群。实验室获得性感染的特定危险因素可能与暴露于含有 N的飞沫或气溶胶有关。脑膜炎。预防应集中在实施II类生物安全柜或在操作疑似脑膜炎球菌隔离株期间进行额外的呼吸防护。

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