Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation

Juergen Loeffler; Michael Steffens; Eva-Maria Arlt; Mohammad-Reza Toliat; Markus Mezger; Anita Suk; Thomas F. Wienker; Holger Hebart; Peter Nürnberg; Michael Boeckh; Per Ljungman; Rudolf Trenschel; Hermann Einsele

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Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation

机译：编码趋化因子受体5，白介素10和单核细胞趋化蛋白1的基因中的多态性有助于同种异体干细胞移植后巨细胞病毒的激活和疾病。

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We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.

机译：我们分析了同种异体干细胞移植后患者免疫功能与人类巨细胞病毒（HCMV）激活和疾病相关的17个基因中的90个多态性。我们发现相关标记（i）CCR5和IL-10基因赋予了HCMV疾病发展更高的风险，以及（ii）与HCMV激活相关的MCP1基因。对高危患者进行这些单核苷酸多态性检测可能有助于个体化抗病毒药物的预防。

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《Journal of Clinical Microbiology》 |2006年第5期|共4页
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Juergen Loeffler; Michael Steffens; Eva-Maria Arlt; Mohammad-Reza Toliat; Markus Mezger; Anita Suk; Thomas F. Wienker; Holger Hebart; Peter Nürnberg; Michael Boeckh; Per Ljungman; Rudolf Trenschel; Hermann Einsele;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells. [J] . Mezger M, Steffens M, Beyer M, Blood: The Journal of the American Society of Hematology . 2008,第2期

机译：趋化因子（C-X-C基序）配体10中的多态性与同种异体干细胞移植后的侵袭性曲霉病相关，并影响单核细胞衍生的树突状细胞中CXCL10的表达。
2. A risk score for early cytomegalovirus reactivation after allogeneic stem cell transplantation identifies low-, intermediate-, and high-risk groups: Reactivation risk is increased by graft-versus-host disease only in the intermediate-risk group [J] . GeorgeB., KerridgeI.H., GilroyN., Transplant infectious disease: an official journal of the Transplantation Society . 2012,第2期

机译：同种异体干细胞移植后早期巨细胞病毒重新激活的风险评分可确定低，中和高风险组：移植物抗宿主病仅在中等风险组中增加了重新激活的风险
3. Genetic polymorphisms in the genes encoding human interleukin-7 receptor-alpha: prognostic significance in allogeneic stem cell transplantation. [J] . Shamim Z, Ryder LP, Heilmann C, Bone marrow transplantation . 2006,第5期

机译：编码人白介素7受体-α的基因中的遗传多态性：在同种异体干细胞移植中的预后意义。
4. THE EFFECT OF INHIBITORY KILLER-CELL IG-LIKE RECEPTOR (IKIR) MATCHING IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION (HCT) [C] . David Senitzer, Joel Y. Sun, Arisa Oki, Clinical Histocompatibility Workshop. . 2009

机译：同种异体造血细胞移植（HCT）中抑制杀伤细胞IG样受体（IKIR）匹配的影响
5. Donor selection for patients undergoing allogeneic hematopoietic stem cell transplantation: Assessment of the priorities of Canadian hematopoietic stem cell transplant physicians. [D] . Tay, Jason. 2009

机译：接受同种异体造血干细胞移植的患者的供体选择：加拿大造血干细胞移植医生的优先事项评估。
6. Polymorphisms in the Genes Encoding Chemokine Receptor 5 Interleukin-10 and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation [O] . Juergen Loeffler, Michael Steffens, Eva-Maria Arlt, 2006

机译：编码趋化因子受体5白介素10和单核细胞趋化蛋白1的基因中的多态性有助于同种异体干细胞移植后巨细胞病毒的激活和疾病。
7. Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation [O] . Loeffler, Juergen, Steffens, Michael, Arlt, Eva-Maria, 2006

机译：编码趋化因子受体5，白介素10和单核细胞趋化蛋白1的基因中的多态性有助于同种异体干细胞移植后巨细胞病毒的激活和疾病。
8. Chemokine Receptor Signatures in Allogeneic Stem Cell Transplantation. [R] . Reshef, R. 2015

机译：同种异体干细胞移植中的趋化因子受体特征。

Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation

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