...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Microbiology >Molecular Epidemiology of Rotavirus in Central and Southeastern Europe
【24h】

Molecular Epidemiology of Rotavirus in Central and Southeastern Europe

机译：中欧和东南欧轮状病毒的分子流行病学

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A surveillance network was implemented by the Istituto Superiore di Sanità of Rome in collaboration with laboratories of virology in Czech Republic, Slovenia, Croatia, Albania, and Bulgaria. About 1,500 rotavirus-positive stool samples were collected from children with severe gastroenteritis admitted to hospitals or outpatient wards between 2004 and 2006. The G and P genotypes were determined by reverse transcription-nested PCR. Significant differences were found in the geographical distributions of rotavirus genotypes between countries participating in the study. The prevalence of “common” G/P combinations, G1P[8], G3P[8], G4P[8], and G2P[4], ranged between 50 and 85%. The G9 genotype, which is emerging worldwide, was identified in 2 to 35% of all samples depending on the country. Unusual combinations, such as G1 or G4 associated with P[4] or G2 with P[8], which may have arisen by reassortment between human strains, were found in samples from 3 to 20% of patients. The uncommon genotypes G8P[8] and G10P[6], which may have an animal origin, were also identified. Double infections with two rotavirus strains were observed in between 1.7 and 14% of cases studied. Our findings might implicate challenges for rotavirus vaccine implementation in a wide geographic area of the Balkans and Central-Eastern Europe and underscore the importance of extensive strain surveillance for success in vaccine development.
机译：罗马高级研究所与捷克共和国，斯洛文尼亚，克罗地亚，阿尔巴尼亚和保加利亚的病毒学实验室合作实施了监视网络。在2004年至2006年之间，从住院或门诊就诊的重度胃肠炎患儿中收集了约1,500个轮状病毒阳性粪便样品。通过反转录巢式PCR确定了G和P基因型。在参与研究的国家之间，轮状病毒基因型的地理分布存在显着差异。 “常见” G / P组合（G1P [8]，G3P [8]，G4P [8]和G2P [4]）的患病率在50％至85％之间。在全球范围内出现的G9基因型在不同国家/地区的所有样本中占2％至35％。在3％至20％的患者样本中发现了异常组合，例如与P [4]相关的G1或G4或与P [8]相关的G2，可能是由于人类品系之间的重配而引起的。还鉴定了可能来自动物的罕见基因型G8P [8]和G10P [6]。在所研究病例的1.7％至14％之间观察到了两种轮状病毒毒株的双重感染。我们的发现可能暗示在巴尔干和中东欧的广阔地理区域中实施轮状病毒疫苗面临的挑战，并强调了广泛的菌株监测对于疫苗开发成功的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号