High Levels of Resistance to Metronidazole and Clarithromycin in Helicobacter pylori Strains in Children

Nicolas Kalach; Michel Bergeret; Pierre Henri Benhamou; Christophe Dupont; Josette Raymond

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High Levels of Resistance to Metronidazole and Clarithromycin in Helicobacter pylori Strains in Children

机译：儿童幽门螺杆菌菌株对甲硝唑和克拉霉素的高水平耐药性

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The aim of the study was to evaluate the prevalence of resistance to amoxicillin, metronidazole, and clarithromycin before treatment ofHelicobacter pylori infection in children and to assess the evolution of resistance with time. The study was carried out between 1994 and 1999 with 150 H. pylori-positive children through gastric culture (antimicrobial susceptibility) and histology. All cultured H. pylori strains were sensitive to amoxicillin, 64 (43%) were resistant to metronidazole, 32 (21%) were resistant to clarithromycin, and 14 (9%) were resistant to both metronidazole and clarithromycin. The overall prevalence of resistance to metronidazole and clarithromycin did not change significantly with time. The study highlights the generalized high-level and stable metronidazole and clarithromycin resistance of H. pylori strains from children.

机译：该研究的目的是评估在治疗儿童幽门螺杆菌感染之前对阿莫西林，甲硝唑和克拉霉素的耐药性流行情况，并评估耐药性随时间的变化。这项研究是在1994年至1999年之间用150 H进行的。胃培养（抗菌药敏感性）和组织学检查的幽门螺杆菌阳性儿童。所有培养的 H。幽门螺杆菌菌株对阿莫西林敏感，对甲硝唑有64（43％）种耐药性，对克拉霉素有32（21％）种耐药性，对甲硝唑和克拉霉素均具有14（9％）种耐药性。甲硝唑和克拉霉素的总体耐药率没有随时间显着变化。该研究突出了 H的普遍的高水平和稳定的甲硝唑和克拉霉素耐药性。来自儿童的幽门螺杆菌菌株。 展开▼

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《Journal of Clinical Microbiology》 |2001年第1期|共4页

作者
Nicolas Kalach; Michel Bergeret; Pierre Henri Benhamou; Christophe Dupont; Josette Raymond;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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专利

1. Mutations in the Antibiotic Target Genes Related to Clarithromycin, Metronidazole and Levofloxacin Resistance in Helicobacter pylori Strains from Children in China [J] . Yanyi Zhang, Yi Wen, Qiulin Xiao, Infection and Drug Resistance . 2020,第1期

机译：与克拉霉素相关的抗生素靶基因中的突变，甲状腺酶，甲状腺藻毒素抗性，来自中国儿童的幽门螺杆菌菌株

2. Role of MIC levels of resistance to clarithromycin and metronidazole in Helicobacter pylori eradication [J] . De Francesco Vincenzo, Zullo Angelo, Fiorini Giulia, The Journal of Antimicrobial Chemotherapy . 2019,第3期

机译：MIC水平对克拉霉素和甲硝唑术中幽门螺杆菌根除的作用

3. High levels of dual resistance to clarithromycin and metronidazole and in vitro activity of levofloxacin against Helicobacter pylori isolates from patients after failure of therapy [J] . Branca G, Spanu T, Cammarota G, International journal of antimicrobial agents . 2004,第5期

机译：治疗失败后患者对克拉霉素和甲硝唑的双重耐药和左氧氟沙星对幽门螺杆菌分离株的体外活性较高

4. Construction of nonlinear fractional order model for clarithromycin against helicobacter pylori and compared with integer order model [C] . Wenchao Wang, Yan Li, Yundong Sun Chinese Automation Congress . 2017

机译：克拉霉素对幽门螺杆菌的非线性分数阶模型的建立及与整数阶模型的比较

5. Development of a novel intragastric controlled release delivery system for simultaneous delivery of metronidazole, tetracycline hydrochloride, colloidal bismuth subcitrate and an H2 receptor antagonist: Used in eradication of Helicobacter pylori associated ulcer. [D] . Wu, Yunqi. 2004

机译：新型胃内控释输送系统的开发，用于同时输送甲硝唑，四环素盐酸盐，胶体次柠檬酸铋和H2受体拮抗剂：用于根除幽门螺杆菌相关溃疡。

6. Note: High Levels of Resistance to Metronidazole and Clarithromycin in Helicobacter pylori Strains in Children [O] . Nicolas Kalach, Michel Bergeret, Pierre Henri Benhamou, 2001

机译：注意：儿童幽门螺杆菌菌株对甲硝唑和克拉霉素的耐药性较高

7. High Levels of Resistance to Metronidazole and Clarithromycin in Helicobacter pylori Strains in Children [O] . Kalach, Nicolas, Bergeret, Michel, Benhamou, Pierre Henri, 2001

机译：儿童幽门螺杆菌菌株对甲硝唑和克拉霉素的高水平耐药性

1. 幽门螺杆菌对克拉霉素、阿莫西林、甲硝唑体外耐药性和敏感性的初步分析 [J] . 陈洁 ,陈飞波 ,余金丹 . 中华儿科杂志 . 2004,第010期

2. 幽门螺杆菌临床菌株克拉霉素耐药性及耐药基因突变位点分析 [J] . 司书梅 ,张涛 ,陈峥宏 . 中国人兽共患病学报 . 2012,第011期

3. 埃索美拉唑、克拉霉素、甲硝唑三联治疗儿童幽门螺杆菌感染的疗效 [J] . 项立 ,卓卫华 ,唐沂 . 中华实用儿科临床杂志 . 2007,第007期

4. 洛赛克、克拉霉素、甲硝唑治疗儿童幽门螺杆菌的疗效观察 [J] . 高源 ,任光运 ,梅红 . 中国现代实用医学杂志 . 2004,第003期

5. 必奇、克拉霉素、甲硝唑三联疗法根除儿童消化性溃疡幽门螺杆菌的疗效观察 [J] . 李爱国 ,龚春华 . 海南医学 . 2003,第010期

6. PCR-RFLP方法快速检测儿童胃黏膜中幽门螺杆菌对克拉霉素的耐药性 [C] . . 中华医学会第五次全国儿科中青年学术交流大会 . 2008

7. 儿童感染幽门螺杆菌体外诱导甲硝唑、克拉霉素、阿莫西林耐药的初步研究 [A] . 颜伟慧 . 2006

1. 幽门螺杆菌阴阳性与克拉霉素耐药性同步检测法 [P] . 中国专利： CN110184331A . 2019-08-30

2. 检测幽门螺杆菌对克拉霉素耐药性试剂盒及制备方法 [P] . 中国专利： CN103103261A . 2013-05-15

3. PRIMER FOR DETECTING HELICOBACTER PYLORI BACTERIUM AND EXAMINATION OF CLARITHROMYCIN RESISTANCE OF HELICOBACTER PYLORI BACTERIUM WITH THE SAME [P] . 外国专利： JPH10286099A . 1998-10-27

机译：用于检测幽门螺杆菌细菌和检测幽门螺杆菌细菌对幽门螺杆菌耐药性的方法

4. Nucleic acid probes peptu00eddico, kit and method for detecting Helicobacter pylori and / or profile of clarithromycin resistance, and applications. [P] . 外国专利： BR112012008336A2 . 2016-11-29

机译：核酸探针肽，用于检测幽门螺杆菌和/或克拉霉素抗性的试剂盒和方法，以及应用。

5. PEPTIDE NUCLEIC ACID PROBES KIT AND METHOD FOR DETECTING HELICOBACTER PYLORI AND/OR CLARITHROMYCIN RESISTANCE PROFILE AND APPLICATIONS [P] . 外国专利： IN2012CN02491A . 2013-05-10

机译：肽核酸探针套件和检测幽门螺杆菌和/或克拉霉素耐药谱的方法和应用

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High Levels of Resistance to Metronidazole and Clarithromycin in Helicobacter pylori Strains in Children

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