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首页> 外文期刊>Journal of Clinical Microbiology >Characterization of Mycobacterium tuberculosis Complex Isolates from the Cerebrospinal Fluid of Meningitis Patients at Six Fever Hospitals in Egypt
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Characterization of Mycobacterium tuberculosis Complex Isolates from the Cerebrospinal Fluid of Meningitis Patients at Six Fever Hospitals in Egypt

机译：埃及六热病医院脑膜炎患者脑脊液中结核分枝杆菌复合物的鉴定

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摘要

Mycobacterium tuberculosis complex isolates from cerebrospinal fluid of 67 meningitis patients were obtained from six fever hospitals in Egypt. One M. bovis and 66 M. tuberculosis isolates were identified by PCR-restriction fragment length polymorphism (RFLP) analysis of oxyR. Among the M. tuberculosis isolates, 53 unique strain types (with 3 to 16 copies of IS6110) were found by RFLP analyses. Nine clusters (eight with two isolates each and one with six isolates) were also found. Thirty-six spoligotypes, including at least 10 that have been previously reported from other countries, were also observed. Forty-one (62.1%) of the isolates were in spoligotype clusters, and 22 (33%) of the isolates were in RFLP clusters. Fifty-one of the isolates were susceptible in vitro to all of the antituberculosis drugs tested, 11 were monoresistant to capreomycin, rifampin, isoniazid (INH), pyrazinamide, or streptomycin (STR), 4 were resistant to STR and INH, and 1 was resistant to STR, INH, and ethambutol.
机译：从埃及的六家发烧医院获得的67例脑膜炎患者脑脊液中的结核分枝杆菌复杂分离株。一个 M。 bovis 和66 M。通过 oxyR 的PCR-限制性片段长度多态性（RFLP）分析鉴定结核菌。在 M中。通过RFLP分析发现了结核病分离株53种独特的菌株（3至16个IS 6110 拷贝）。还发现了九个簇（八个，每个带有两个分离株，一个带有六个分离株）。还观察到了36种血型，其中至少有10种以前从其他国家报告过。其中有41个（62.1％）的分离物位于spoligotype簇中，有22个（33％）的分离物位于RFLP簇中。分离株中有51个在体外对所有测试的抗结核药物敏感，其中11种对卡普霉素，利福平，异烟肼（INH），吡嗪酰胺或链霉素（STR）单抗，4种对STR和INH耐药，对STR，INH和乙胺丁醇具有抗性。

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