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Assessment of Evolution of Pandemic Vibrio parahaemolyticus by Multilocus Sequence Typing

机译：多基因座序列分型评估大流行副溶血性弧菌的进化

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The genetic relatedness of 81 isolates of Vibrio parahaemolyticus was assessed by multilocus sequence typing. The strain with serotype O3:K6 emerged as a pandemic pathogen in 1996, with subsequent expansion to include strains having serotypes O1:KUT, O4:K68, and O1:K25. Sequence data from gyrB, recA, dnaE, and gnd revealed that 16 distinct serogroups isolated prior to the pandemic were highly variable and only isolates of serogroup O3:K6 shared two alleles with the pandemic strains. The pandemic strains regardless of serotype were clonal, with 51 of 54 isolates having the identical allelic profile (AP). Serotype alone did not adequately define a pandemic strain: among O1:KUT strains tested, seven strains with the identical pandemic AP carried previously described pandemic markers, while five nonpandemic strains had five distinct APs. Our sequence data provide strong molecular support for the clonal origin of pandemic V. parahaemolyticus O3:K6 and suggest that strains within such a clonal group may acquire previously identified serotypes.
机译：通过多基因座序列分型来评估81株副溶血性弧菌的遗传相关性。具有血清型O3：K6的菌株于1996年作为大流行病原体出现，随后扩展到包括具有血清型O1：KUT，O4：K68和O1：K25的菌株。来自 gyrB ， recA ， dnaE 和 gnd 的序列数据显示，在大流行之前分离出16个不同的血清群O3：K6血清群的高度可变且仅有分离株与大流行株共享两个等位基因。不论血清型如何，大流行毒株都是克隆的，在54个分离株中有51个具有相同的等位基因特征（AP）。单独的血清型不能充分确定大流行毒株：在测试的O1：KUT菌株中，具有相同大流行性AP的7株带有先前描述的大流行标记，而五个非大流行株具有5个不同的AP。我们的序列数据为大流行性流感V的克隆起源提供了强有力的分子支持。副溶血菌O3：K6，并表明这种克隆组中的菌株可能获得先前鉴定的血清型。

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