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首页> 外文期刊>Journal of Clinical Microbiology >Genotyping of Methicillin-Resistant Staphylococcus aureus Strains from Two Hospitals in Bangalore, South India
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Genotyping of Methicillin-Resistant Staphylococcus aureus Strains from Two Hospitals in Bangalore, South India

机译：来自印度南部班加罗尔两家医院的耐甲氧西林金黄色葡萄球菌菌株的基因分型

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Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen in India, and up to 70% methicillin resistance has been reported from hospitals in various parts of India. Hospitals use phenotyping for the most part, and molecular genotyping is not done. Here we report on the genotyping of 82 single-patient isolates from two hospitals in Bangalore, South India, for the first time. Most of the strains possessed type III or IIIA staphylococcal cassette chromosome (SCCmec) cassettes, and we did not detect strains with type I, IA, or II cassettes. Most isolates also contained the type III cassette chromosome recombinase (ccr) AB region. Multilocus sequence typing (MLST) and staphylococcal protein A (spa) typing of a selected number of isolates have been carried out. Although most isolates that were chosen for MLST and spa typing had the same patterns, they were quite diverse in their pulsed-field gel electrophoresis (PFGE) patterns. PFGE, MLST, and spa typing of the Indian strains revealed that they are related to the previously described Hungarian and Brazilian clones.
机译：耐甲氧西林的金黄色葡萄球菌（MRSA）是印度的主要医院病原体，印度各地的医院都报告说甲氧西林的耐药性高达70％。医院大部分使用表型，而分子基因型还没有完成。在这里，我们首次报告了印度南部印度班加罗尔的两家医院的82名单患者分离株的基因型。大多数菌株具有III型或IIIA型葡萄球菌盒染色体（ SCCmec ）盒，我们没有检测到具有I，IA或II型盒的菌株。大多数分离株还含有III型盒式染色体重组酶（ ccr ）AB区。已经进行了选定数目的分离株的多基因座序列分型（MLST）和葡萄球菌蛋白A（ spa ）分型。尽管选择用于MLST和 spa 分型的大多数分离株具有相同的模式，但它们的脉冲场凝胶电泳（PFGE）模式却非常不同。 PFGE，MLST和 spa 对印度菌株的分型显示，它们与先前描述的匈牙利和巴西克隆有关。

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