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首页> 外文期刊>Journal of Clinical Microbiology >Staphylococcus aureus Strains Isolated from Bloodstream Infections Changed Significantly in 2006
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Staphylococcus aureus Strains Isolated from Bloodstream Infections Changed Significantly in 2006

机译：从血流感染中分离出的金黄色葡萄球菌菌株在2006年发生了显着变化

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We studied 358 Staphylococcus aureus strains isolated from bloodstream infections (BSI) observed during an epidemiological study covering 2,007,681 days of hospitalization in 32 healthcare institutions (HCIs) between 2004 and 2006. The strains were tested for antibiotic susceptibility and characterized genetically. The incidence of S. aureus BSI declined regularly through 2004 and 2005 and then significantly increased in 2006 (+80%). This was largely due to an increase in BSI involving methicillin-sensitive S. aureus (MSSA) strains and nonmultiresistant methicillin-resistant S. aureus (NORSA) strains. Ninety-six percent of the NORSA strains were resistant only to methicillin and fluoroquinolones. Most of the MSSA strains belonged to a small number of pulsed-field gel electrophoresis (PFGE) divisions and were associated with epidemic phenomena in HCIs. The NORSA strains also clustered into a limited number of PFGE divisions but could not be related to any local outbreak in HCIs. In 2006, there was a significant increase in the incidence of BSI associated with tst gene-positive MSSA strains (+275%) and the first three BSI associated with tst gene-positive MRSA were observed. PFGE data revealed a limited heterogeneity among the tst gene-positive strains without any outbreak in the HCIs. Our study underlines the need for infection control teams to focus efforts on preventing both MRSA and MSSA BSI. As recently demonstrated in vitro, fluoroquinolones may enhance horizontal transfer of virulence and antibiotic resistance genes. These antibiotics are widely used in France, so our findings raise the issue of whether their use has contributed to the acquisition of mecA and tst genes by S. aureus strains.
机译：我们对2004年至2006年间在32个医疗机构（HCI）进行的住院期间2,007,681天的流行病学研究中发现的358株从血流感染（BSI）中分离出的金黄色葡萄球菌（BSI）菌株进行了测试。具有遗传特征。 S的发生率。金黄色葡萄球菌的BSI在2004年和2005年一直定期下降，然后在2006年显着上升（+ 80％）。这主要是由于涉及甲氧西林敏感的 S的BSI升高。金黄色葡萄球菌（MSSA）菌株和耐多甲氧西林的 S。金黄色葡萄球菌（NORSA）菌株。 96％的NORSA菌株仅对甲氧西林和氟喹诺酮类药物具有抗药性。大多数MSSA菌株属于少数的脉冲场凝胶电泳（PFGE）部门，并且与HCI中的流行现象有关。 NORSA菌株也聚集在有限数量的PFGE分区中，但与HCI的任何局部暴发无关。 2006年，与 tst 基因阳性的MSSA菌株相关的BSI发生率显着增加（+ 275％），而与 tst 基因相关的前三个BSI-观察到阳性MRSA。 PFGE数据显示 tst 基因阳性菌株之间的异质性有限，而在HCI中没有任何爆发。我们的研究强调感染控制团队需要集中精力预防MRSA和MSSA BSI。正如最近在体外证明的那样，氟喹诺酮类药物可能会增强毒力和抗生素抗性基因的水平转移。这些抗生素在法国广泛使用，因此我们的发现提出了一个问题，即它们的使用是否有助于 S获得 mecA 和 tst 基因。金黄色葡萄球菌

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