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首页> 外文期刊>Journal of Clinical Microbiology >Genotypic Characteristics of Staphylococcus aureus Isolates from a Multinational Trial of Complicated Skin and Skin Structure Infections
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Genotypic Characteristics of Staphylococcus aureus Isolates from a Multinational Trial of Complicated Skin and Skin Structure Infections

机译：复杂皮肤和皮肤结构感染的跨国试验中金黄色葡萄球菌分离株的基因型特征

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The impact of bacterial genetic characteristics on the outcome of patients with Staphylococcus aureus infections is uncertain. This investigation evaluated potential associations between bacterial genotype and clinical outcome using isolates collected as part of an international phase 2 clinical trial (FAST II) evaluating telavancin for the treatment of complicated skin and skin structure infections (cSSSI). Ninety S. aureus isolates from microbiologically evaluable patients with cSSSI enrolled in the FAST II trial from 11 sites in the United States (56 isolates, or 62%) and 7 sites in South Africa (34 isolates, or 38%) were examined for staphylococcal cassette chromosome mec, agr, and the presence of 31 virulence genes and subjected to pulsed-field gel electrophoresis (PFGE). South African methicillin-susceptible S. aureus (MSSA) isolates were more likely to carry certain virulence genes, including sdrD (P = 0.01), sea (P < 0.01), and pvl (P = 0.01). All 44 (49%) methicillin-resistant S. aureus (MRSA) isolates were from the United States; 37 (84%) were strain USA 300 by PFGE. In the United States, MRSA isolates were more likely than MSSA isolates to carry genes for sdrC (P = 0.03), map/eap (P = 0.05), fnbB (P = 0.11), tst (P = 0.02), sea (P = 0.04), sed (P = 0.04), seg (P = 0.11), sej (P = 0.11), agr (P = 0.09), V8 (P = 0.06), sdrD, sdrE, eta, etb, and see (P < 0.01 for all). MRSA isolates were more often clonal than MSSA isolates by PFGE. Isolates from patients who were cured were significantly more likely to contain the pvl gene than isolates from patients that failed or had indeterminate outcomes (79/84 [94%] versus 3/6 [50%]; P = 0.01). S. aureus strains from different geographic regions have different distributions of virulence genes.
机译：细菌遗传学特征对金黄色葡萄球菌感染患者预后的影响尚不确定。这项研究使用细菌分离作为国际2期临床试验（FAST II）的一部分，评估了细菌基因型与临床结果之间的潜在关联，该试验评估特拉万星用于治疗复杂的皮肤和皮肤结构感染（cSSSI）。九十个在FAST II试验中，对来自微生物学评估的cSSSI患者的金黄色葡萄球菌分离物进行了检查，这些分离物来自美国的11个场所（56个菌株，占62％）和南非的7个场所（34个菌株，占38％）。葡萄球菌盒式染色体 mec ， agr ，并存在31个毒力基因，并进行脉冲场凝胶电泳（PFGE）。南非对甲氧西林敏感的 S。金黄色葡萄球菌（MSSA）分离物更可能携带某些毒力基因，包括 sdrD （ P = 0.01）， sea （< em> P <0.01）和 pvl （ P = 0.01）。所有44（49％）耐甲氧西林的 S。金黄色葡萄球菌（MRSA）分离株来自美国; PFGE的菌株USA 300为37（84％）。在美国，MRSA分离物比MSSA分离物更可能携带 sdrC （ P = 0.03）， map / eap （< em> P = 0.05）， fnbB （ P = 0.11）， tst （ P = 0.02）， sea （ P = 0.04）， sed （ P = 0.04）， seg < / em>（ P = 0.11）， sej （ P = 0.11）， agr （ P = 0.09）， V8 （ P = 0.06）， sdrD ， sdrE ， eta ， etb 和请参见（所有 P <0.01）。与PFGE分离的MSSA分离株相比，MRSA分离株更常见。与治愈失败或结果不确定的患者分离出的细菌相比，治愈后的细菌分离出的 pvl 基因的可能性更高（79/84 [94％]对3/6 [50％]; em> P = 0.01）。 S。不同地理区域的金黄色葡萄球菌菌株的毒力基因分布不同。

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