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首页> 外文期刊>Journal of Clinical Microbiology >Clinical Predictive Value of Real-Time PCR Quantification of Human Cytomegalovirus DNA in Amniotic Fluid Samples
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Clinical Predictive Value of Real-Time PCR Quantification of Human Cytomegalovirus DNA in Amniotic Fluid Samples

机译：羊水样品中人巨细胞病毒DNA实时PCR定量的临床预测价值

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摘要

The aim of this study was to evaluate the diagnostic reliability and prognostic significance of the quantification of cytomegalovirus (CMV) DNA in amniotic fluid (AF). We retrospectively reviewed the results for 282 amniotic fluid samples that had been tested for CMV by a quantitative real-time PCR. We observed three cases in which no CMV genomes were detected in the AF but in which the children were nevertheless congenitally infected. Hence, we conclude that a negative result by PCR for CMV in AF cannot rule out the possibility of congenital infection. No false-positive PCR results were observed. A correlation between the CMV viral load in AF and the fetal and neonatal outcomes could not be demonstrated in our study. Instead, a correlation was found between the CMV viral load and the gestational age at the time of amniocentesis.
机译：这项研究的目的是评估定量羊水（AF）中巨细胞病毒（CMV）DNA的诊断可靠性和预后意义。我们回顾性地回顾了通过定量实时PCR检测的282份羊水样本的结果。我们观察到了3例在AF中未检测到CMV基因组但仍先天感染儿童的病例。因此，我们得出结论，对于AF中CMV的PCR阴性结果不能排除先天性感染的可能性。没有观察到假阳性PCR结果。在我们的研究中无法证明房颤的CMV病毒载量与胎儿和新生儿结局之间的相关性。取而代之的是，在羊膜腔穿刺术时，CMV病毒载量与胎龄之间存在相关性。

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