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首页> 外文期刊>Journal of Clinical Microbiology >Acrophialophora, a Poorly Known Fungus with Clinical Significance
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Acrophialophora, a Poorly Known Fungus with Clinical Significance

机译：Acrophialophora，一种鲜为人知的真菌，具有临床意义

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Acrophialophora fusispora is an emerging opportunistic fungus capable of causing human infections. The taxonomy of the genus is not yet resolved and, in order to facilitate identification of clinical specimens, we have studied a set of clinical and environmental Acrophialophora isolates by morphological and molecular analyses. This set included the available type strains of Acrophialophora species and similar fungi, some of which were considered by various authors to be synonyms of A. fusispora. Sequence analysis of the large subunit (LSU) and internal transcribed spacer (ITS) regions of the nuclear ribosomal DNA and a fragment of the β-tubulin (Tub) gene revealed that Acrophialophora belongs in the family Chaetomiaceae and comprises three different species, i.e., A. fusispora, Acrophialophora levis, and Acrophialophora seudatica; the latter was previously included in the genus Ampullifera. The most prevalent species among clinical isolates was A. levis (72.7%), followed by A. fusispora (27.3%), both of which were isolated mostly from respiratory specimens (72.7%), as well as subcutaneous and corneal tissue samples. In general, of the eight antifungal drugs tested, voriconazole had the greatest in vitro activity, while all other agents showed poor in vitro activity against these fungi.
机译：Acrophialophora fusispora是一种新兴的机会真菌，能够引起人类感染。该属的分类法尚未解决，为了促进临床标本的鉴定，我们通过形态学和分子分析研究了一组临床和环境的Acrophialophora分离株。该组包括可用的Acrophialophora种和类似真菌的类型菌株，其中的一些被不同作者认为是fusispora的同义词。核糖体DNA大亚基（LSU）和内部转录间隔区（ITS）区域以及β-微管蛋白（ Tub ）基因片段的序列分析表明，Acrophialophora属于Chaetomiaceae科和包括三种不同的物种，即：A。fusispora，Les Acrophialophora和Acrophialophora seudatica。后者以前被包括在壶腹属中。在临床分离株中，最常见的物种是Levis A. levis（72.7％），其次是fusispora（27.3％），二者均主要从呼吸道标本（72.7％）以及皮下和角膜组织样品中分离出来。通常，在测试的八种抗真菌药物中，伏立康唑的体外活性最高，而所有其他药物对这些真菌的体外活性均较弱。

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