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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Epidemiology of Haemophilus influenzae Type b Causing Vaccine Failures in the United Kingdom
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Molecular Epidemiology of Haemophilus influenzae Type b Causing Vaccine Failures in the United Kingdom

机译：在英国导致疫苗失败的b型流感嗜血杆菌的分子流行病学

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Haemophilus influenzae type b (Hib) was a major cause of pediatric disease in the United Kingdom prior to the introduction of routine Hib immunization in 1992. An unexpected resurgence of cases of vaccine failure was observed with fully vaccinated children from 1999 onward. We investigated whether Hib isolates causing vaccine failures in the United Kingdom could have undergone a change in their population structure to elude the protective effect of Hib vaccine. Molecular epidemiology studies were carried out with 376 isolates from invasive infections (164 vaccine failures and 212 controls). Genetic variability was higher in controls than in vaccine failures. Of the four major clusters obtained, cluster I comprised 92.2% of the total isolates: 156 vaccine failures (95%) and 193 (91%) controls. Cluster IV was specific for vaccine failures but included only four isolates. The increased number of cases of invasive Hib in fully vaccinated children in the United Kingdom was caused by isolates belonging not to a particular or new genotype but to genotypes already circulating in the prevaccination era, before conjugate Hib vaccines were available.
机译：在1992年开始常规Hib免疫之前，流感嗜血杆菌 b型（Hib）是英国小儿疾病的主要原因。在完全接种疫苗的儿童中，疫苗接种失败的病例意外地再次出现从1999年开始。我们调查了在英国导致疫苗失败的Hib分离株是否可能经历了种群结构的变化，从而逃避了Hib疫苗的保护作用。对来自侵入性感染的376株细菌进行了分子流行病学研究（164例疫苗失败和212例对照）。对照中的遗传变异性高于疫苗失败时的遗传变异性。在获得的四个主要簇中，簇I占总分离株的92.2％：156例疫苗失败（95％）和193例（91％）对照。第四类针对疫苗失败，但仅包括四个分离株。在英国，完全接种疫苗的儿童中侵袭性Hib病例数的增加是由于分离物不属于特定或新基因型，而属于结合前Hib疫苗可用之前在预疫苗时代已经流行的基因型。

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