New and Sensitive Assay for Determining Pseudomonas aeruginosa Metallo-Beta-Lactamase Resistance to Imipenem

Jingyuan Tan; Johann D. D. Pitout; David S. Guttman

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New and Sensitive Assay for Determining Pseudomonas aeruginosa Metallo-Beta-Lactamase Resistance to Imipenem

机译：测定铜绿假单胞菌金属β-内酰胺酶对亚胺培南抗药性的新方法

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We present an imipenem lysate metallo-beta-lactamase (MBL) functional assay. This assay eliminates false-positive results due to the bactericidal effects of EDTA, can be performed with inexpensive reagents available in most laboratories, and is as accurate as the MBL Etest. It is appropriate for both high-accuracy screens and laboratories in developing countries with limited resources.

机译：我们提出了亚胺培南裂解物金属-β-内酰胺酶（MBL）功能测定。该测定消除了由于EDTA的杀菌作用而导致的假阳性结果，可以使用大多数实验室中可用的廉价试剂进行，并且与MBL Etest一样准确。它适用于资源有限的发展中国家的高精度筛查和实验室。

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《Journal of Clinical Microbiology》 |2008年第5期|共3页
作者
Jingyuan Tan; Johann D. D. Pitout; David S. Guttman;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Overproduction of a metallo-beta-lactamase by a strong promoter causes high-level imipenem resistance in a clinical isolate of Pseudomonas aeruginosa. [J] . Takeda S, Nakai T, Ikeda F, Chemotherapy: International Journal of Experimental and Clinical Chemotherapy . 2008,第3期

机译：强启动子过量生产金属-β-内酰胺酶会在临床分离的铜绿假单胞菌中引起高水平的亚胺培南耐药性。
2. Phenotypic and Molecular Detection of Metallo-Beta-Lactamase Genes Among Imipenem Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Strains Isolated From Patients with Burn Injuries [J] . Samira Tarashi, Hossein Goudarzi, Soroor Erfanimanesh, Archives of clinical infectious diseases. . 2016,第4期

机译：烧伤患者分离的亚胺培南耐药铜绿假单胞菌和鲍曼不动杆菌菌株中金属-内酰胺酶基因的表型和分子检测
3. Phenotypic and Molecular Detection of Metallo-Beta-Lactamase Genes Among Imipenem Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Strains Isolated From Patients with Burn Injuries [J] . Ali Hashemi, Ali Pormohammad, Hossein Goudarzi, Iranian journal of clinical infectious diseases . 2016,第4期

机译：烧伤患者分离的亚胺培南耐药铜绿假单胞菌和鲍曼不动杆菌菌株中金属-内酰胺酶基因的表型和分子检测
4. Using SESI-MS to determine volatile biomarkers released from Pseudomonas aeruginosa under antibiotic stress [C] . Yin-Ming Kuo, Jane E. Hill American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用SESI-MS确定在抗生素应激下从假单胞菌铜绿假单胞菌释放的挥发生物标志物
5. Determining the Mechanism and Regulation of the Heme Assimilation System (Has) in Pseudomonas aeruginosa Heme Signaling and Acquisition [D] . Dent, Alecia Tennessee. 2020

机译：测定血红素同化系统（具有）在铜绿假单胞菌血红素信号传导和采集中的机制和调节
6. New and Sensitive Assay for Determining Pseudomonas aeruginosa Metallo-Beta-Lactamase Resistance to Imipenem [O] . Jingyuan Tan, Johann D. D. Pitout, David S. Guttman 2008

机译：测定铜绿假单胞菌金属β-内酰胺酶对亚胺培南抗药性的新方法
7. New and Sensitive Assay for Determining Pseudomonas aeruginosa Metallo-Beta-Lactamase Resistance to Imipenem▿ † [O] . Tan, Jingyuan, Pitout, Johann D. D., Guttman, David S. 2008

机译：测定铜绿假单胞菌对β-亚胺培南的金属-β-内酰胺酶耐药性的新方法

New and Sensitive Assay for Determining Pseudomonas aeruginosa Metallo-Beta-Lactamase Resistance to Imipenem

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